Document Detail

Insulin resistance and associated metabolic abnormalities in muscle: effects of exercise.
MedLine Citation:
PMID:  12119637     Owner:  NLM     Status:  MEDLINE    
Skeletal muscle is a major site of insulin resistance. In addition to glucose transport, oxidative disposal and storage defects, insulin resistant muscle exhibit many other metabolic abnormalities. After a brief review of insulin resistance determinants, we will focus on muscular abnormalities in obesity and type 2 diabetes. Glucose and lipid metabolism defects will be analysed and their interactions discussed. Exercise can improve many of these muscular abnormalities and the mechanisms underlying exercise-induced benefits have been clarified during the past decades. Therefore, exercise training has proved to be useful in the management of insulin resistant states, i.e. mainly obesity, especially in its truncal distribution, and type 2 diabetes. However, exercise prescription remains poorly codified, and results on glycaemic control are sometimes conflicting. In the last part of this review, we will emphasize the pathophysiological basis for an individualized exercise prescription in insulin resistant subjects.
A Pérez-Martin; E Raynaud; J Mercier
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Obesity reviews : an official journal of the International Association for the Study of Obesity     Volume:  2     ISSN:  1467-7881     ISO Abbreviation:  Obes Rev     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2002-07-17     Completed Date:  2002-08-01     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  100897395     Medline TA:  Obes Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  47-59     Citation Subset:  IM    
Service Central de Physiologie Clinique, Unité CERAMM (Centre d'Exploration et de Réadaptation des Anomalies Métaboliques et Musculaires), CHU Lapeyronie 34295 Montpellier, France.
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MeSH Terms
Blood Glucose / metabolism
Diabetes Mellitus, Type 2 / metabolism*
Insulin Resistance* / genetics
Lipids / blood
Muscle, Skeletal / metabolism*
Obesity / metabolism*
Reg. No./Substance:
0/Blood Glucose; 0/Lipids

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