Document Detail

Insulin requirements in insulin-dependent and insulin-requiring GDM women during final month of pregnancy.
MedLine Citation:
PMID:  1425097     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the significance of falling insulin requirements after the 36th wk of gestation in insulin-requiring pregnant women. RESEARCH DESIGN AND METHODS: Insulin requirements of women with IDDM and IRGDM were assessed from the 36th wk of pregnancy, with evaluation of maternal characteristics and fetal outcomes. RESULTS: In 32 pregnancies of women with IDDM, there was a 5 +/- 2% decrease in insulin requirements, and in 19 pregnancies of women with IRGDM, there was a 28 +/- 10% increase. Of the 62% of women whose insulin requirements declined, the decrement was 12 +/- 2% and was associated with longer duration of diabetes (12 +/- 2 vs. 6 +/- 1 yr, P less than 0.05) but not with age, prepregnancy BMI, weight gain, or maternal or fetal complications. Only 3 pregnancies in IRGDM women were associated with a decrease in insulin requirements. Although maternal parameters were no different from those with IDDM, infants born to women with IRGDM were smaller (3531 +/- 123 vs. 3874 +/- 94 g, P less than 0.005). CONCLUSIONS: Insulin requirements from the 36th wk of gestation commonly decreased in women with IDDM, associated with longer duration of diabetes but did not carry any adverse prognostic indication for the infants. Women with IRGDM experienced a continual increase in insulin requirements over the final weeks of pregnancy.
R M McManus; E A Ryan
Related Documents :
25185847 - Hyperthyroidism during pregnancy - the role of measuring maternal tsh receptor antibodi...
11561477 - Prevalence of diabetes mellitus among pregnant women receiving health services at the p...
12194917 - Predictive value of routine circulating soluble endothelial cell adhesion molecule meas...
1304787 - Normal levels of glycosylated haemoglobin in pregnant nigerian women.
23271027 - The potential significance of binovular follicles and binucleate giant oocytes for the ...
11495557 - Acyclovir suppression to prevent clinical recurrences at delivery after first episode g...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diabetes care     Volume:  15     ISSN:  0149-5992     ISO Abbreviation:  Diabetes Care     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1992-12-02     Completed Date:  1992-12-02     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  7805975     Medline TA:  Diabetes Care     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1323-7     Citation Subset:  IM    
Division of Endocrinology and Metabolism, University of Alberta, Edmonton, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bilirubin / blood
Birth Weight
Diabetes Mellitus, Type 1 / drug therapy*
Diabetes, Gestational / drug therapy*
Dose-Response Relationship, Drug
Hyperglycemia / epidemiology
Hypoglycemia / epidemiology
Infant, Newborn
Insulin / therapeutic use*
Pregnancy in Diabetics / drug therapy*
Retrospective Studies
Treatment Outcome
Weight Gain
Reg. No./Substance:
11061-68-0/Insulin; 635-65-4/Bilirubin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  High incidence rate of IDDM in Sardinia. Sardinian Collaborative Group for Epidemiology of IDDM.
Next Document:  Relationship of postload plasma glucose to mortality with 19-yr follow-up. Comparison of one versus ...