Document Detail

Insulin requirements for hepatic regeneration following hepatectomy.
MedLine Citation:
PMID:  831634     Owner:  NLM     Status:  MEDLINE    
On the basis of changes in the adenine nucleotide the mitochondrial metabolism of the remnant liver, insulin requirements for hepatic regeneration were studied in diabetic rats treated with varying amounts of alloxan. Mildly diabetic rats with less than 30% inhibition in maximal portal insulin response to oral glucose load, showed a parabolic glucose tolerance pattern and could tolerate partial hepatectomy. Whereas, severely diabetic rats with more than 45% inhibition showed a linear glucose tolerance pattern and died within 24 hours after partial hepatectomy. In the former rats, the energy charge (ATP + 1/2ADP/ATP + ADP + AMP) levels of the remnant liver decrease slightly at an early period after partial hepatectomy but could be restored rapidly to normal levels with a concomitant rise of oxidative phosphorylation in remnant liver mitochondria. In contrast, the energy charge levels in the latter groups fell more markedly and could not be restored, because of insufficient enhancement of mitochondrial oxidative phosphorylation. It is suggested that an enhancement in mitochondrial phosphorylative activity of the remnant liver following partial hepatectomy is inhibited in proportion to the severity of impaired insulin secretion, resulting in a decrease of the potential functional capacity of liver.
T Yamada; M Yamamoto; K Ozawa; I Honjo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of surgery     Volume:  185     ISSN:  0003-4932     ISO Abbreviation:  Ann. Surg.     Publication Date:  1977 Jan 
Date Detail:
Created Date:  1977-02-26     Completed Date:  1977-02-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372354     Medline TA:  Ann Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  35-42     Citation Subset:  AIM; IM    
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MeSH Terms
Adenine Nucleotides / metabolism
Diabetes Mellitus, Experimental / metabolism
Glucose Tolerance Test
Insulin / pharmacology,  secretion*
Liver / analysis,  drug effects,  metabolism
Liver Regeneration / drug effects
Mitochondria, Liver / metabolism
Reg. No./Substance:
0/Adenine Nucleotides; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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