Document Detail

Insulin-receptor activity in nondiabetic and diabetic urbanized South African black women.
MedLine Citation:
PMID:  1547686     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate insulin receptor binding characteristics of urbanized South African black women with normal glucose tolerance and of patients with newly diagnosed untreated non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS: Four groups of 10 subjects each were selected by the following criteria: group A, young (20-39 yr) nonobese (body mass index [BMI] 19.0-24.9 kg/m2) nondiabetic women; group B, middle-aged (40-60 yr) nonobese nondiabetic women; group C, middle-aged obese (BMI greater than 30.0 kg/m2) nondiabetic women; and group D, middle-aged obese newly diagnosed but untreated female patients with NIDDM. Insulin binding to monocyte receptors was determined by radioreceptor assay. Fasting plasma samples were analyzed for glucose, insulin, C-peptide, and nonesterified fatty acids. RESULTS: In the four groups studied, maximum specific binding and receptor concentration were highest in group A, with a progressive and significant decrease in values through groups B and C to group D. Significant inverse correlations were obtained between maximum specific binding, 50% inhibition dose, and total receptor concentration on the one hand and glucose, insulin, and NEFA on the other. CONCLUSIONS: Our study of urban South African black women showed decreasing insulin-receptor activity with obesity and glucose intolerance. In patients with NIDDM, hyperglycemia and beta-cell dysfunction were associated with a reduction in receptor concentration. In this regard, our findings in South African blacks are consistent with results of similar studies of NIDDM in other communities.
V R Panz; B I Joffe; J R Wing; F J Raal; H C Seftel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabetes care     Volume:  15     ISSN:  0149-5992     ISO Abbreviation:  Diabetes Care     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-04-21     Completed Date:  1992-04-21     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  7805975     Medline TA:  Diabetes Care     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  277-81     Citation Subset:  IM    
Carbohydrate and Lipid Metabolism Research Group, University of the Witwatersrand Medical School, Johannesburg, South Africa.
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MeSH Terms
African Continental Ancestry Group
Age Factors
Blood Glucose / metabolism
C-Peptide / blood
Diabetes Mellitus / blood*
Fatty Acids, Nonesterified / blood
Insulin / blood
Middle Aged
Monocytes / metabolism*
Obesity / blood*
Receptor, Insulin / metabolism*
Reference Values
South Africa
Urban Population
Reg. No./Substance:
0/Blood Glucose; 0/C-Peptide; 0/Fatty Acids, Nonesterified; 11061-68-0/Insulin; EC, Insulin

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