| Insulin pump dosing across gestation in women with well-controlled type 1 diabetes mellitus. | |
| | |
MedLine Citation:
|
PMID: 23021699 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
OBJECTIVE: We hypothesized that bolus and basal insulin doses in women with type 1 diabetes mellitus who use insulin pumps would increase 2-fold to maintain hemoglobin A1c <6.5% across gestation. STUDY DESIGN: This was a retrospective study of 9 women with type 1 diabetes mellitus with preconceptional hemoglobin A1c ≤7.4% using insulin pumps. The primary outcome was absolute and percentage change of basal and bolus insulin from preconception to delivery. RESULTS: Total daily dose of insulin increased from 33.3 ± 7.8 U/d before conception to 93.5 ± 27.9 U/d at delivery. Basal rates rose modestly (50% increase, from 16.2 ± 6.5 U/d to 24.0 ± 9 U/d); bolus insulin doses quadrupled from 17.1 ± 6.1 U/d to 69.5 ± 29.6 U/d (P = .0001). Bolus insulin increased from approximately 50% of total daily dose of insulin before conception to 75% of total daily dose of insulin at 36 weeks' gestation. CONCLUSION: In well-controlled type 1 diabetes mellitus, insulin requirements increased 3-fold from before conception to 36 weeks' gestation. Most of this requirement was attributed to an increase in bolus rates that are required for control with meals. |
| | |
Authors:
|
Hilary A Roeder; Thomas R Moore; Gladys A Ramos |
Related Documents
:
|
19893789 - Diabetic retinopathy screening in general practice: a pilot study. 11530969 - Predictors of carotid endarterectomy in middle-aged individuals. 23467919 - Preoperatively determinable factors predictive of diabetes mellitus remission following... 23128859 - Comparative effectiveness of sulfonylurea and metformin monotherapy on cardiovascular e... 23399919 - Illness representations of type 2 diabetes patients are associated with perceptions of ... 23241069 - A review of the efficacy and safety of oral antidiabetic drugs. 23142159 - Impact of socioeconomic status on diabetes and cardiovascular risk factors: results of ... 2993299 - Insulin-stimulated phosphoinositide metabolism in isolated fat cells. 6994939 - The effect of long-term diphenylhydantoin therapy on glucose tolerance and insulin secr... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: American journal of obstetrics and gynecology Volume: 207 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-10-01 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
|
Languages: eng Pagination: 324.e1-5 Citation Subset: AIM; IM |
Copyright Information:
|
Copyright © 2012 Mosby, Inc. All rights reserved. |
Affiliation:
|
Division of Perinatology, Department of Reproductive Medicine, UC San Diego Health System, San Diego, CA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prevalence and risk factors of cerebral lesions in neonates after laser surgery for twin-twin transf...
Next Document: Epidural-associated hypotension is more common among severely preeclamptic patients in labor.