Document Detail


Insulin production following intravenous glucose, arginine, and valine: different pattern in patients with impaired glucose tolerance and non-insulin-dependent diabetes mellitus.
MedLine Citation:
PMID:  8139489     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To better understand abnormal insulin production (IP) in states of carbohydrate intolerance, insulin release was quantified following equimolar (2.4 mmol/kg) infusions of glucose, arginine, and valine in healthy subjects ([HS] age, 45 +/- 3 years; body mass index [BMI, kg/m2], 26.3 +/- 2.4; means +/- SEM), obese subjects with impaired glucose tolerance ([IGT] age, 43 +/- 5 years; BMI, 35.4 +/- 2.4), and non-obese patients with chronic non-insulin-dependent diabetes mellitus ([NIDDM] age, 55 +/- 3 years; BMI, 26.4 +/- 1.4; duration of disease, 13 +/- 3 years). There were eight subjects per group. Incremental IP (metabolic clearance rate of C-peptide [MCRCP] x total incremental area under the curve of plasma C-peptide [AUCCP], pmol/kg) following substrate infusion was as follows: glucose: HS, 227 +/- 14; IGT, 1,050 +/- 184 (P < .001 v HS); NIDDM, 114 +/- 27 (P < .001 v HS); arginine: HS, 139 +/- 23; IGT, 488 +/- 106 (P < .01 v HS); NIDDM, 206 +/- 47; and valine: HS, 21 +/- 7; IGT, 32 +/- 10; NIDDM, 54 +/- 12 (P < .01 v HS). The fractional clearance rate ([FCR] k, %/min) was impaired in IGT and NIDDM for glucose (HS, 3.9 +/- 0.4; IGT, 2.3 +/- 0.3 [P < .01 v HS]; NIDDM, 1.4 +/- 0.1 [P < .001 v HS]), arginine (2.4 +/- 0.1; 1.9 +/- 0.2 [P < .01 v HS]; 1.9 +/- 0.2 [P < .01 v HS]), and valine (0.95 +/- 0.06; 0.65 +/- 0.09 [P < .05 v HS]; 0.74 +/- 0.1 [P < .05 v HS]).(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
P Fasching; K Ratheiser; P Nowotny; S Uurzemann; S Parzer; W Waldhäusl
Related Documents :
10963829 - Comparison of who and ada criteria for diagnosis of glucose status in adults.
19783009 - Role of the oral glucose tolerance test (ogtt) in the idiopathic restless legs syndrome.
17544539 - Fibrinolytic dysfunction after gestation is associated to components of insulin resista...
8894499 - Effects of troglitazone on insulin sensitivity.
20605249 - Characteristics of insulin resistance and insulin secretory capacity in korean subjects...
20627649 - A large proportion of prediabetes and diabetes goes undiagnosed when only fasting plasm...
11524629 - The insulin, glucose and cholesterol level and activity of lysosomal enzymes in the cou...
17244209 - Glycodelin: a novel serum anti-inflammatory marker in type 1 diabetic retinopathy durin...
142349 - Quantitative morphological analysis of glomerular changes of the rabbit kidney on treat...
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  43     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-04-26     Completed Date:  1994-04-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  385-9     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine III, University of Vienna, Austria.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Arginine / administration & dosage,  pharmacology*
Blood Glucose / analysis
Body Mass Index
C-Peptide / blood
Diabetes Mellitus, Type 2 / blood,  metabolism*
Female
Glucose / administration & dosage,  pharmacology*
Glucose Intolerance / blood,  metabolism*
Humans
Injections, Intravenous
Insulin / blood,  metabolism*
Male
Middle Aged
Valine / administration & dosage,  pharmacology*
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/C-Peptide; 11061-68-0/Insulin; 50-99-7/Glucose; 7004-03-7/Valine; 74-79-3/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Leucine kinetics during a brief fast in diabetes in pregnancy.
Next Document:  Interrelationships between intraabdominal fat and total serum testosterone levels in obese women.