Document Detail

Insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBP-1, -2 and -3) in diabetic pregnancy: relationship to macrosomia.
MedLine Citation:
PMID:  9026269     Owner:  NLM     Status:  MEDLINE    
To evaluate the role of insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) in excessive fetal growth (macrosomia) in diabetic pregnancy, 84 insulin-treated diabetic mothers and their infants were tested for serum concentrations of IGF-I, IFG-II, and IGFBP-1, -2 and -3. These parameters were correlated with the birth weight of neonates and placental weight. IGF-I and II levels were determined by specific radioimmunoassays (RIAs) after serum samples were extracted with aid-ethanol. IGFBPs were measured by Western immunoblot with specific antibodies to the respective IGFBP species. Serum concentrations of both IGF-I and IGF-II in mothers with either IDDM or NIDDM increased with the gestational period, reached a plateau at the third trimester, and returned to non-pregnant levels within 7 days after delivery. These values were not different from those in normal mothers before and throughout pregnancy. As previously reported, IGF-I concentrations in cord serum of neonates born to diabetic mothers were (P < 0.01) higher than those of newborns of normal mothers. Likewise, cord blood IGF-II levels were 2-fold higher in babies of diabetic mothers (P <0.001). Fetal IGF-I and IGF-II correlated with each other and with maternal HbA1C, and they positively correlated with either birth weight or placental weight. Cord IGFBP-3 concentrations were significantly higher in diabetic pregnancy, but IGFBP-2 concentrations were not different from those in normal pregnancy. Cord IGFBP-1 concentrations were significantly higher only in babies of mothers with IDDM. None of these cord IGFBP concentrations correlated with birth weight or placental weight. The data suggest that fetal IGF-II, like IGF-I, is involved in fetal and placental growth in diabetic pregnancy. The role of IGFBPs remained to be determined.
L Yan-Jun; T Tsushima; S Minei; M Sanaka; T Nagashima; K Yanagisawa; Y Omori
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Endocrine journal     Volume:  43     ISSN:  0918-8959     ISO Abbreviation:  Endocr. J.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1997-02-19     Completed Date:  1997-02-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9313485     Medline TA:  Endocr J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  221-31     Citation Subset:  IM    
Department of Medicine III (Diabetes Center), Tokyo Women's Medical College, Japan.
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MeSH Terms
Birth Weight
Blotting, Western
Diabetes Mellitus, Type 1 / blood
Diabetes Mellitus, Type 2 / blood
Fetal Blood / metabolism
Fetal Macrosomia / blood*
Insulin-Like Growth Factor Binding Protein 1 / blood
Insulin-Like Growth Factor Binding Protein 2 / blood
Insulin-Like Growth Factor Binding Protein 3 / blood
Insulin-Like Growth Factor Binding Proteins / blood*
Insulin-Like Growth Factor I / metabolism*
Insulin-Like Growth Factor II / metabolism*
Pregnancy in Diabetics / blood*
Reg. No./Substance:
0/Insulin-Like Growth Factor Binding Protein 1; 0/Insulin-Like Growth Factor Binding Protein 2; 0/Insulin-Like Growth Factor Binding Protein 3; 0/Insulin-Like Growth Factor Binding Proteins; 67763-96-6/Insulin-Like Growth Factor I; 67763-97-7/Insulin-Like Growth Factor II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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