| Insulin-like growth factor-I treatment in two children with growth hormone gene deletions. | |
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MedLine Citation:
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PMID: 10417965 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two unrelated Brazilian patients had homozygous 6.7 kb deletions in the GH-1 gene (girl and boy, 1.8 and 3.3 yr, heights -7.9 and -6.0 SDS, respectively). Desensitization using small amounts of exogenous GH (0.033 IU/kg body weight/week, divided into daily s.c. injections) was attempted, but anti-GH antibodies appeared. Replacement with usual doses of hGH induced only transient increase in growth. IGF-I therapy with increasing doses resulted in catch-up growth without side-effects. Growth velocity was 7.5 cm/yr in the first year and 8.4 cm/yr in the next 6 months in patient 1, and 6.7 cm/yr in the first year, 5.9 cm/yr in the second year and 7.9 cm/yr in the third year of IGF-I treatment in patient 2, when the daily dose of 240 micrograms/kg was divided into three injections. IGFBP-3 levels were low (0.55 and 0.40 mg/I) and did not increase after IGF-I treatment, suggesting that this GH effect is not mediated by IGF-I, and injected IGF-I had a rapid disappearance rate. We conclude that IGF-I promotes growth by endocrine mechanisms and constitutes an effective treatment for patients with GH insensitivity secondary to GH antibodies. |
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Authors:
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I J Arnhold; S B Oliveira; M G Osorio; B B Mendonca |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of pediatric endocrinology & metabolism : JPEM Volume: 12 ISSN: 0334-018X ISO Abbreviation: J. Pediatr. Endocrinol. Metab. Publication Date: 1999 Jul-Aug |
Date Detail:
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Created Date: 1999-08-26 Completed Date: 1999-08-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9508900 Medline TA: J Pediatr Endocrinol Metab Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 499-506 Citation Subset: IM |
Affiliation:
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Unidade de Endocrinologia do Desenvolvimento, Hospital das Clinicas, University of São Paulo School of Medicine, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies
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blood Body Height Brazil Child, Preschool Female Gene Deletion* Growth Disorders / drug therapy, genetics Hormone Replacement Therapy Human Growth Hormone / genetics*, immunology, therapeutic use Humans Infant Insulin-Like Growth Factor Binding Protein 3 / blood Insulin-Like Growth Factor I / administration & dosage, therapeutic use* Male |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Insulin-Like Growth Factor Binding Protein 3; 12629-01-5/Human Growth Hormone; 67763-96-6/Insulin-Like Growth Factor I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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