Document Detail


Insulin-like growth factor I stimulates active Na(+)-K+ transport in rat soleus muscle.
MedLine Citation:
PMID:  7762637     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The functional homology between insulin and insulin-like growth factor I (IGF-I) comprises effects on growth and glucose metabolism. Because insulin stimulates the Na(+)-K+ pump, IGF-I might exert a similar effect. We show here that IGF-I increases 42K and 86Rb uptake and the efflux of 22Na in isolated rat soleus muscle. This leads to a significant decrease (21-55%, P < 0.001) in intracellular Na+ and a small increase in intracellular K+. In extensor digitorum longus (EDL) muscle, similar effects were observed. The stimulation of K+ uptake and the reduction in intracellular Na+ in the soleus were blocked by ouabain, indicating that they reflect an acute stimulation of active Na(+)-K+ transport. This conclusion was further supported by the observation that the [3H]ouabain binding rate was significantly increased by IGF-I. IGF-I increased ouabain-suppressible 42K or 86Rb uptake by 56 and 54%, respectively. The effects of IGF-I and epinephrine on ouabain-suppressible 86Rb influx in rat soleus were additive, whereas the effects of insulin and IGF-I were similar and nonadditive. The effects of IGF-I were seen down to a concentration of 10(-8) M, which is unlikely to stimulate the insulin receptor, and it is therefore plausible that IGF-I exerts its effect on Na(+)-K+ transport through its own receptor. IGF-I may play a role in the maintenance of muscle Na+ and K+ contents also in vivo, especially in patients treated with IGF-I.
Authors:
I Dørup; T Clausen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  268     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-06-29     Completed Date:  1995-06-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E849-57     Citation Subset:  IM    
Affiliation:
Institute of Physiology, University of Aarhus, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carrier Proteins / metabolism*
Epinephrine / pharmacology
Female
Hindlimb
Insulin / pharmacology
Insulin-Like Growth Factor I / pharmacology*
Male
Muscle, Skeletal / metabolism*
Ouabain / metabolism
Potassium / metabolism
Rats
Rats, Wistar
Rubidium / pharmacokinetics
Sodium / metabolism
Sodium-Potassium-Chloride Symporters
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Sodium-Potassium-Chloride Symporters; 11061-68-0/Insulin; 51-43-4/Epinephrine; 630-60-4/Ouabain; 67763-96-6/Insulin-Like Growth Factor I; 7440-09-7/Potassium; 7440-17-7/Rubidium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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