| Insulin-like growth factor I stimulates growth in normal growing rats. | |
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MedLine Citation:
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PMID: 3732389 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The scarcity of purified somatomedin/insulin-like growth factor (SM/IGF) has prevented investigation of the mechanisms of SM/IGF action. Recently insulin-like growth factor I (IGF-I) has been synthesized by recombinant DNA technology. The availability of large quantities of the biosynthetic IGF-I made it possible to study its effects by administering 120 micrograms/day via s.c. implanted minipump to rats for 7 days. After this 7 day administration of IGF-I, the body weight increased to 197.6 +/- 3.5% of initial values; the value was significantly greater than that of the control (179.4 +/- 3.7% of initial values, P less than 0.01). The body length and tibial epiphyseal width in IGF-I-treated rats were also significantly increased over those of control rats. The weights of kidneys, liver, testes and pituitary in IGF-I-treated rats were greater than those in control rats as well. These results provide a first demonstration that IGF-I stimulates growth in normal rats in vivo, and suggest that IGF-I might be useful in the treatment of growth retardation. |
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Authors:
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N Hizuka; K Takano; K Shizume; K Asakawa; M Miyakawa; I Tanaka; R Horikawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of pharmacology Volume: 125 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1986 Jun |
Date Detail:
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Created Date: 1986-09-16 Completed Date: 1986-09-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 143-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight / drug effects Growth / drug effects* Growth Plate / drug effects Insulin-Like Growth Factor I / blood, pharmacology* Male Organ Size / drug effects Rats Rats, Inbred Strains Somatomedins / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Somatomedins; 67763-96-6/Insulin-Like Growth Factor I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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