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Insulin-like growth factor I receptor density on CD4+T-lymphocytes from active early steroid- and DMARD-naïve rheumatoid arthritis patients is up-regulated and not influenced by 1 year of clinically effective treatment.
MedLine Citation:
PMID:  21246373     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The IGF-IR density on CD4+T-lymphocytes was studied using flow cytometry in 40 early steroid- and DMARD-naïve rheumatoid arthritis (RA) patients before and after 52 weeks of treatment with methotrexate+placebo or methotrexate+cyclosporine A and in 15 controls. RA patients had increased IGF-IR density on CD4+T-lymphocytes at week 0 and week 52, irrespective of treatment. IGF-IR-positive CD4+T-lymphocytes fraction decreased during treatment, but neither at week 0 nor at week 52 did it differ from healthy controls. No correlations were found to disease activity parameters.
Authors:
Trine Bay Laurberg; Torkell Ellingsen; Jonas Thorsen; Bjarne Kuno Møller; Ib Hansen; Ulrik Tarp; Merete Lund Hetland; Kim Hørslev-Petersen; Allan Flyvbjerg; Jan Frystyk; Kristian Stengaard-Pedersen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-19
Journal Detail:
Title:  Rheumatology international     Volume:  -     ISSN:  1437-160X     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Rheumatology, Aarhus University Hospital, Norrebrogade 44, Building A1, 8000, Aarhus, Denmark, trine_bay@dadlnet.dk.
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