| Insulin-like growth factor I promotes growth selectively in fetal sheep in late gestation. | |
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MedLine Citation:
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PMID: 8928919 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Insulin-like growth factor I (IGF-I) is required for normal fetal growth and skeletal maturation in late gestation, because null mutations of the IGF-I gene in mice reduce fetal weight and retard ossification of bones. To determine if, conversely, increased abundance of IGF-I promotes fetal growth and skeletal maturation, fetal sheep were infused intravascularly with recombinant human IGF-I (n = 7) (26 +/- 3 micrograms. h-1.kg-1) from 120 to 130 days gestation and compared with controls (n = 15). IGF-I infusion increased plasma IGF-I concentrations by 140% (P = 0.002) and weights of fetal liver, lungs, heart, kidneys, spleen, pituitary, and adrenal glands by 16-50% (P < 0.05). Weights and/or lengths of the fetus, placenta, gastrointestinal tract, individual skeletal muscles, and long bones were unchanged by IGF-I. However, IGF-I increased the percentage of proximal epiphyses of long bones present (P < 0.05) and their cross-sectional areas by 15 to 38% (P < 0.05). These results show that IGF-I promotes growth of major fetal organs, endocrine glands, and skeletal maturation in vivo, consistent with IGF-I actively controlling and not merely facilitating fetal growth. The variable response of different tissues may partly reflect tissue specificity in growth requirements for additional factors. |
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Authors:
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F Lok; J A Owens; L Mundy; J S Robinson; P C Owens |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 270 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1996 May |
Date Detail:
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Created Date: 1996-11-27 Completed Date: 1996-11-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R1148-55 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, University of Adelaide, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Development / drug effects* Embryonic and Fetal Development / drug effects* Female Fetal Blood Fetus / anatomy & histology Humans Insulin / blood Insulin-Like Growth Factor I / analysis, pharmacology* Insulin-Like Growth Factor II / analysis Musculoskeletal System / embryology Placenta / anatomy & histology Pregnancy Recombinant Proteins Sheep / embryology |
| Chemical | |
Reg. No./Substance:
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0/Recombinant Proteins; 11061-68-0/Insulin; 67763-96-6/Insulin-Like Growth Factor I; 67763-97-7/Insulin-Like Growth Factor II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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