Document Detail

Insulin-like growth factor pathway genes and blood concentrations, dietary protein and risk of prostate cancer in the NCI Breast and Prostate Cancer Cohort Consortium (BPC3).
MedLine Citation:
PMID:  23341348     Owner:  NLM     Status:  MEDLINE    
It has been hypothesized that a high intake of dairy protein may increase prostate cancer risk by increasing the production of insulin-like growth factor 1 (IGF-1). Several single nucleotide polymorphisms (SNPs) have been weakly associated with circulating concentrations of IGF-1 and IGF binding protein 3 (IGFBP-3), but none of these SNPs was associated with risk of prostate cancer. We examined whether an association between 16 SNPs associated with circulating IGF-1 or IGFBP-3 concentrations and prostate cancer exists within subgroups defined by dietary protein intake in 5,253 cases and 4,963 controls of European ancestry within the NCI Breast and Prostate Cancer Cohort Consortium (BPC3). The BPC3 includes nested case-control studies within large North-American and European cohorts. Per-allele odds ratios for prostate cancer for the SNPs were compared across tertiles of protein intake, which was expressed as the percentage of energy derived from total, animal, dairy or plant protein sources, using conditional logistic regression models. Total, animal, dairy and plant protein intakes were significantly positively associated with blood IGF-1 (p < 0.01), but not with IGFBP-3 concentrations (p > 0.10) or with risk of prostate cancer (p > 0.20). After adjusting for multiple testing, the SNP-prostate cancer associations did not differ by intakes of protein, although two interactions by intake of plant protein were of marginal statistical significance [SSTR5 (somatostatin receptor 5)-rs197056 (uncorrected p for interaction, 0.001); SSTR5-rs197057 (uncorrected p for interaction, 0.002)]. We found no strong evidence that the associations between 16 IGF pathway SNPs and prostate cancer differed by intakes of dietary protein.
Konstantinos K Tsilidis; Ruth C Travis; Paul N Appleby; Naomi E Allen; Sara Lindström; Demetrius Albanes; Regina G Ziegler; Marjorie L McCullough; Afshan Siddiq; Aurelio Barricarte; Sonja I Berndt; H Bas Bueno-de-Mesquita; Stephen J Chanock; E David Crawford; W Ryan Diver; Susan M Gapstur; Edward Giovannucci; Fangyi Gu; Christopher A Haiman; Richard B Hayes; David J Hunter; Mattias Johansson; Rudolf Kaaks; Laurence N Kolonel; Peter Kraft; Loic Le Marchand; Kim Overvad; Silvia Polidoro; Elio Riboli; Fredrick R Schumacher; Victoria L Stevens; Dimitrios Trichopoulos; Jarmo Virtamo; Walter C Willett; Timothy J Key
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-02-15
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  133     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-05-15     Completed Date:  2013-07-11     Revised Date:  2014-08-05    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  495-504     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 UICC.
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MeSH Terms
Body Mass Index
Case-Control Studies
Cohort Studies
Insulin-Like Growth Factor Binding Protein 3 / blood,  genetics*
Insulin-Like Growth Factor I / genetics*,  metabolism
Middle Aged
Models, Biological
Odds Ratio
Polymorphism, Single Nucleotide
Prostatic Neoplasms / blood,  genetics*
Regression Analysis
Risk Factors
Grant Support
11692//Cancer Research UK; U01 CA098216/CA/NCI NIH HHS; U01 CA098233/CA/NCI NIH HHS; U01 CA098710/CA/NCI NIH HHS; U01 CA098758/CA/NCI NIH HHS; U01-CA98216-06/CA/NCI NIH HHS; U01-CA98233-07/CA/NCI NIH HHS; U01-CA98710-06/CA/NCI NIH HHS; U01-CA98758-07/CA/NCI NIH HHS
Reg. No./Substance:
0/Insulin-Like Growth Factor Binding Protein 3; 67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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