| Insulin-like growth factor-I in growth and metabolism. | |
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MedLine Citation:
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PMID: 20432800 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Deficiency of insulin-like growth factor-I (IGF-I) results in growth failure. A variety of molecular defects have been found to underlie severe primary IGF-I deficiency (IGFD), in which serum IGF-I concentrations are substantially decreased and fail to respond to GH therapy. Identification of more patients with primary or secondary IGFD is likely with investigative and diagnostic progress, particularly in the assessment of children with idiopathic short stature. Diagnosis of IGFD requires accurate and reliable IGF-I assays, adequate normative data for reference, and knowledge of IGF-I physiology for proper interpretation of data. Recombinant human IGF-I (rhIGF-I) treatment improves stature in patients with severe primary IGFD, and has also been shown to improve glycaemic control and insulin sensitivity in patients with severe insulin resistance. Ongoing studies of patients receiving rhIGF-I will allow further evaluation of the clinical utility of this treatment, with concurrent increase in our understanding of IGF-I and conditions of IGFD. |
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Authors:
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P Backeljauw; P Bang; D B Dunger; A Juul; Y Le Bouc; R Rosenfeld |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of pediatric endocrinology & metabolism : JPEM Volume: 23 ISSN: 0334-018X ISO Abbreviation: J. Pediatr. Endocrinol. Metab. Publication Date: 2010 Jan-Feb |
Date Detail:
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Created Date: 2010-05-03 Completed Date: 2010-05-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508900 Medline TA: J Pediatr Endocrinol Metab Country: England |
Other Details:
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Languages: eng Pagination: 3-16 Citation Subset: IM |
Affiliation:
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Division of Pediatric Endocrinology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chemistry, Clinical
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standards Child Energy Metabolism / physiology* Growth Disorders / diagnosis*, drug therapy, metabolism* Humans Insulin Resistance / physiology* Insulin-Like Growth Factor I / deficiency, metabolism*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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67763-96-6/Insulin-Like Growth Factor I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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