| Insulin-like growth factor axis (insulin-like growth factor-I/insulin-like growth factor-binding protein-3) as a prognostic predictor of heart failure: association with adiponectin. | |
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MedLine Citation:
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PMID: 20851819 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Insulin-like growth factor (IGF)-I is a regulator of glucose/fatty acid metabolism and may be involved in the pathophysiology of cardiovascular disease, but it remains unclear whether endogenous IGF-I is associated with the prognosis of heart failure (HF). We investigated whether the IGF axis, the ratio of IGF-I to IGF-binding protein-3 (IGFBP-3), was a predictor of clinical outcomes in HF. The association of IGF axis with serum adiponectin level, a prognostic marker of HF as well as a regulator of glucose/fatty acid metabolism, was also analysed. METHODS AND RESULTS: We measured serum IGF-I and IGFBP-3 in 142 HF patients with left ventricular systolic dysfunction and 63 control subjects. Patients with HF underwent clinical assessment and measurement of adiponectin and B-type natriuretic peptide (BNP). Compared with controls, HF patients showed significantly decreased serum IGF axis values [median (inter-quartile ranges), 0.114 (0.063-0.150) vs. 0.099 (0.052-0.158), P = 0.042]. In HF patients, the log-transformed IGF axis values were inversely correlated with the log-transformed serum adiponectin levels (r = -0.35, P < 0.0001) and plasma BNP levels (r = -0.25, P = 0.0028). The IGF axis was lower in patients with New York Heart Association (NYHA) functional class III/IV than those with class I/II [0.071 (0.044-0.145) vs. 0.107 (0.068-0.161), P = 0.022]. Furthermore, a decrease in IGF axis was associated with increased rates of all-cause mortality (P = 0.013), cardiac death (P = 0.035), and a composite of cardiac death and re-hospitalization (P = 0.0085). CONCLUSION: Insulin-like growth factor axis is a significant predictor of clinical outcomes in HF and is significantly associated with serum adiponectin levels. |
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Authors:
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Shin Watanabe; Toshihiro Tamura; Koh Ono; Hisanori Horiuchi; Takeshi Kimura; Toru Kita; Yutaka Furukawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-17 |
Journal Detail:
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Title: European journal of heart failure Volume: 12 ISSN: 1879-0844 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-22 Completed Date: 2011-03-14 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1214-22 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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physiology* Aged Aged, 80 and over Female Heart Failure / blood*, mortality*, physiopathology Humans Insulin-Like Growth Factor Binding Protein 3 / analysis, physiology* Insulin-Like Growth Factor I / analysis, physiology* Male Middle Aged Multivariate Analysis Natriuretic Peptide, Brain / blood Prognosis Proportional Hazards Models |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Insulin-Like Growth Factor Binding Protein 3; 114471-18-0/Natriuretic Peptide, Brain; 67763-96-6/Insulin-Like Growth Factor I |
| Comments/Corrections | |
Comment In:
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Eur J Heart Fail. 2010 Nov;12(11):1154-5
[PMID:
20923855
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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