Document Detail

Insulin-like growth factor (IGF)-I and IGF-II stimulate progesterone production by human luteal cells: role of IGF-I as mediator of growth hormone action.
MedLine Citation:
PMID:  8690108     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the possible direct effect of insulin-like growth factor (IGF)-I and IGF-II on basal and hCG-stimulated P production by cultured human luteal cells. The possible role of IGF-I as mediator of GH action on luteal steroidogenesis also was investigated. DESIGN: Cultures of human luteal cells from early and midluteal phase. SETTING: All corpora lutea were obtained from the Obstetrics and Gynecology Department of the Universita Cattolica, a public care center. PATIENTS: Eight nonpregnant women between 35 and 47 years of age underwent surgery for various nonendocrine disorders such as leiomyomatosis. INTERVENTIONS: Corpora lutea were obtained at the time of hysterectomy. MAIN OUTCOME MEASURES: Luteal cells were incubated with IGF-I or IGF-II with or without hCG at different concentrations. Growth hormone also was used alone and with an anti-IGF-I-antibody. RESULTS: We found that IGF-I and IGF-II were able to stimulate directly the P production at all used concentrations and that both of them significantly amplified the steroidogenic hCG effect. Finally, IGF-I was shown to mediate the positive GH action on P synthesis.
R Apa; N Di Simone; E Ronsisvalle; F Miceli; D de Feo; A Caruso; A Lanzone; S Mancuso
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  66     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1996-08-29     Completed Date:  1996-08-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  235-9     Citation Subset:  IM    
Institute of Obstetrics and Gynecology, Università Cattolica del SacroCuore, Rome, Italy.
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MeSH Terms
Cells, Cultured
Chorionic Gonadotropin / pharmacology
Dose-Response Relationship, Drug
Drug Synergism
Growth Hormone / physiology*
Insulin-Like Growth Factor I / pharmacology*,  physiology*
Insulin-Like Growth Factor II / pharmacology*
Luteal Cells / cytology,  drug effects,  metabolism*
Middle Aged
Progesterone / metabolism*
Reg. No./Substance:
0/Chorionic Gonadotropin; 57-83-0/Progesterone; 67763-96-6/Insulin-Like Growth Factor I; 67763-97-7/Insulin-Like Growth Factor II; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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