| Insulin-like growth factor (IGF)-I, IGF binding protein (IGFBP)-3, phosphoisoforms of IGFBP-1 and postnatal growth in very-low-birth-weight infants. | |
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MedLine Citation:
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PMID: 14671409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Small preterm infants experience a unique postnatal period characterized by slow growth, inadequate nutrition and growth inhibiting treatments. Many have already been growth-restricted in utero. Studying this period is important when developing growth optimizing strategies for these infants and, in a broader context, as a model of extreme conditions that restrict growth. By following short-term growth of 48 very-low-birth-weight (VLBW; birth weight <1,500 g) infants for 9 postnatal weeks, we found that circulating insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)-3 levels are low and reflect rigorously measured (knemometry and weight) concurrent growth velocity. Moreover, weight growth velocity is correlated with the ratio of lesser to highly phosphorylated IGFBP-1 but not with absolute IGFBP-1 concentrations. Thus, IGF-I, IGFBP-3 and the phosphorylation status of IGFBP-1 in circulation are likely to be involved in growth regulation during the postnatal period in VLBW infants. |
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Authors:
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Eero Kajantie |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Hormone research Volume: 60 Suppl 3 ISSN: 0301-0163 ISO Abbreviation: Horm. Res. Publication Date: 2003 |
Date Detail:
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Created Date: 2003-12-12 Completed Date: 2004-09-17 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0366126 Medline TA: Horm Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 124-30 Citation Subset: IM |
Copyright Information:
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Copyright 2003 S. Karger AG, Basel |
Affiliation:
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Helsinki University Central Hospital, Hospital for Children and Adolescents, Helsinki, Finland. eero.kajantie@helsinki.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Fetal Growth Retardation
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metabolism Gestational Age Humans Infant Nutritional Physiological Phenomena Infant, Newborn Infant, Very Low Birth Weight / growth & development* Insulin-Like Growth Factor Binding Protein 1 / genetics Insulin-Like Growth Factor Binding Protein 3 / physiology* Insulin-Like Growth Factor I / physiology* Leg / growth & development Phosphorylation Protein Isoforms / physiology Regression Analysis |
| Chemical | |
Reg. No./Substance:
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0/Insulin-Like Growth Factor Binding Protein 1; 0/Insulin-Like Growth Factor Binding Protein 3; 0/Protein Isoforms; 67763-96-6/Insulin-Like Growth Factor I |
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