Document Detail

Insulin-like growth factor (IGF)-I, IGF binding protein (IGFBP)-3, phosphoisoforms of IGFBP-1 and postnatal growth in very-low-birth-weight infants.
MedLine Citation:
PMID:  14671409     Owner:  NLM     Status:  MEDLINE    
Small preterm infants experience a unique postnatal period characterized by slow growth, inadequate nutrition and growth inhibiting treatments. Many have already been growth-restricted in utero. Studying this period is important when developing growth optimizing strategies for these infants and, in a broader context, as a model of extreme conditions that restrict growth. By following short-term growth of 48 very-low-birth-weight (VLBW; birth weight <1,500 g) infants for 9 postnatal weeks, we found that circulating insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)-3 levels are low and reflect rigorously measured (knemometry and weight) concurrent growth velocity. Moreover, weight growth velocity is correlated with the ratio of lesser to highly phosphorylated IGFBP-1 but not with absolute IGFBP-1 concentrations. Thus, IGF-I, IGFBP-3 and the phosphorylation status of IGFBP-1 in circulation are likely to be involved in growth regulation during the postnatal period in VLBW infants.
Eero Kajantie
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Hormone research     Volume:  60 Suppl 3     ISSN:  0301-0163     ISO Abbreviation:  Horm. Res.     Publication Date:  2003  
Date Detail:
Created Date:  2003-12-12     Completed Date:  2004-09-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0366126     Medline TA:  Horm Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  124-30     Citation Subset:  IM    
Copyright Information:
Copyright 2003 S. Karger AG, Basel
Helsinki University Central Hospital, Hospital for Children and Adolescents, Helsinki, Finland.
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MeSH Terms
Fetal Growth Retardation / metabolism
Gestational Age
Infant Nutritional Physiological Phenomena
Infant, Newborn
Infant, Very Low Birth Weight / growth & development*
Insulin-Like Growth Factor Binding Protein 1 / genetics
Insulin-Like Growth Factor Binding Protein 3 / physiology*
Insulin-Like Growth Factor I / physiology*
Leg / growth & development
Protein Isoforms / physiology
Regression Analysis
Reg. No./Substance:
0/Insulin-Like Growth Factor Binding Protein 1; 0/Insulin-Like Growth Factor Binding Protein 3; 0/Protein Isoforms; 67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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