Document Detail

Insulin-like growth factor-I E peptides: implications for aging skeletal muscle.
MedLine Citation:
PMID:  19883387     Owner:  NLM     Status:  MEDLINE    
In skeletal muscle there is good evidence to suggest that locally produced insulin-like growth factor-1 (IGF-I), rather than circulating IGF-I, is important in regard to muscle mass maintenance, repair and hypertrophy. This "mature" IGF-I comprises exons 3 and 4 of the IGF-I gene, but during processing the full length gene (which contains six exons) is subject to a process of alternative splicing. As a result smaller peptides (E peptides) are believed to be cleaved from the mature IGF-I peptide during processing of the prohormone and the likelihood is that they have different biological roles. In human skeletal muscle three transcripts encoding for these splice variants (IGF-IEa, IGF-IEb and IGF-IEc, also known as MGF) can be identified. When studied at the mRNA level these three transcripts are known to be upregulated in the muscles of elderly people following high resistance exercise, albeit with different time courses. However, compared with mature IGF-I relatively little is known about the mechanism of action of the different E peptides.
Cristina P Velloso; Stephen D R Harridge
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Scandinavian journal of medicine & science in sports     Volume:  20     ISSN:  1600-0838     ISO Abbreviation:  Scand J Med Sci Sports     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-05-21     Completed Date:  2010-09-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111504     Medline TA:  Scand J Med Sci Sports     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  20-7     Citation Subset:  IM    
Division of Applied Biomedical Research, King's College London, London, UK.
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MeSH Terms
Aging / physiology*
Alternative Splicing
Cell Proliferation
Exercise / physiology
Gene Transfer Techniques
Insulin-Like Growth Factor I / chemistry,  physiology*
Muscle, Skeletal / physiology*
Protein Isoforms
RNA, Messenger / chemistry
Sarcopenia / physiopathology
Satellite Cells, Skeletal Muscle / physiology
Reg. No./Substance:
0/Protein Isoforms; 0/RNA, Messenger; 67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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