Document Detail

Insulin-like growth factor 1 and pressure load in hypertensive patients.
MedLine Citation:
PMID:  8783786     Owner:  NLM     Status:  MEDLINE    
To verify the effect of a pressure load on the production of Insulin-like Growth Factor 1 (IGF1) in essential hypertensives, we studied 15 patients and 8 normotensive controls before and during orthostatism. Upright standing was characterized both in normals and in hypertensives by significant higher rate-pressure product [RPP = systolic blood pressure (mm Hg) x heart rate (beats/min)]. Proportional increases of RPP were significantly related to IGF1 values at the end of orthostatism and to proportional increases of IGF1 in hypertensive group but not in normotensive one. Our results confirm that IGF1 plasma levels in hypertensive patients are related to pressure load.
G Andronico; M T Mangano; L Ferrara; D Lamanna; G Mulè; G Cerasola
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  American journal of hypertension     Volume:  9     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-11-27     Completed Date:  1996-11-27     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  607-9     Citation Subset:  IM; S    
Division of Clinical Pathophysiology and Hypertension, University of Palermo, Italy.
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MeSH Terms
Blood Pressure / physiology*
Heart Rate / physiology
Hypertension / metabolism*,  physiopathology
Hypotension, Orthostatic
Insulin-Like Growth Factor I / biosynthesis*
Posture / physiology*
Reg. No./Substance:
67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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