| Insulin-like growth factor-1 levels in twins and its correlation with discordance. | |
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MedLine Citation:
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PMID: 21314261 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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This study aims to determine whether fetal growth is related to insulin-like growth factor-1 in dichorionic and monochorionic twins and also aims to investigate the correlation of insulin-like growth factor-1 to birthweight discordance in twins. We studied 100 women with twin pregnancies. The correlation tests of 36 discordant twins (15 monochorionic, 21 dichorionic) showed correlation between insulin-like growth factor-1 difference and birthweight discordance (insulin-like growth factor-1 vs. birthweight of first twin, r = +0.915, at 0.01 level, IGF-1 vs birthweight of second twin r = +0.790, at 0.01 level). In 49 monochorionic twins, independent of discordance, there was a correlation between birthweight discordance and insulin-like growth factor-1 difference (r = .538, at the 0.01 level). This correlation was not significant in dichorionic twins, r = .144, p = .01. These data suggest that growth discordances of twins exposed to the same maternal environment may be due to variations in IGF-1, depending upon the genetic similarity. |
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Authors:
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Fuat Emre Canpolat; Ferhat Cekmez; Serdar Ümit Sarici; Ayşe Korkmaz; Murat Yurdakok |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Twin research and human genetics : the official journal of the International Society for Twin Studies Volume: 14 ISSN: 1832-4274 ISO Abbreviation: Twin Res Hum Genet Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101244624 Medline TA: Twin Res Hum Genet Country: Australia |
Other Details:
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Languages: eng Pagination: 94-7 Citation Subset: IM |
Affiliation:
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1 Hacettepe University Faculty of Medicine, Department of Pediatrics, Ankara, Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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