Document Detail


Insulin-like growth factor-1 (IGF-1) and IGF-1 receptor (IGF-1R) expression in human lung in RDS and BPD.
MedLine Citation:
PMID:  14730658     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We hypothesize that IGF-1 and IGF-1R proteins are upregulated in lung epithelia and fibroblasts in RDS compared to normal development, and are further upregulated in BPD. We used immunohistochemistry to evaluate IGF-1 and IGF-R expression in lungs from autopsies of human stillbirths and RDS and BPD patients. IGF-1 and IGF-R immunostaining were present in fetal, RDS, and BPD lungs. In RDS, IGF-1 was present in alveolar epithelium and prominent in columnar and cuboidal airway epithelia. In BPD lungs, immunostaining was intensely increased in both airway and alveolar epithelia and in mesenchyme. The immunostaining index in bronchial epithelial cells and peribronchial myofibroblasts was significantly higher in BPD compared to RDS. IGF-1R expression was minimal in fetal lung and found mainly in mesenchyme. IGF-1R was increased in mesenchyme in RDS. In BPD it was especially increased in peribronchial and perialveolar mesenchyme. Immunostaining index for IGF-1R in epithelial cells and peribronchial myofibroblasts was increased in BPD compared to RDS. IGF-1 and IGF-R expression is low during fetal development, but is acutely upregulated in RDS, and persists with further upregulation in BPD.
Authors:
Anne Chetty; Sture Andersson; Patrik Lassus; Heber C Nielsen
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatric pulmonology     Volume:  37     ISSN:  8755-6863     ISO Abbreviation:  Pediatr. Pulmonol.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-01-19     Completed Date:  2004-06-24     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  8510590     Medline TA:  Pediatr Pulmonol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  128-36     Citation Subset:  IM    
Copyright Information:
Copyright 2004 Wiley-Liss, Inc.
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MeSH Terms
Descriptor/Qualifier:
Bronchopulmonary Dysplasia / metabolism*,  pathology
Female
Humans
Immunohistochemistry
Infant, Newborn
Insulin-Like Growth Factor I / metabolism*
Lung / metabolism*,  pathology
Muscle, Smooth / metabolism,  pathology
Pregnancy
Pregnancy Outcome
Receptor, IGF Type 1 / metabolism*
Respiratory Distress Syndrome, Newborn / metabolism*,  pathology
Up-Regulation
Grant Support
ID/Acronym/Agency:
67089//PHS HHS; HL37930/HL/NHLBI NIH HHS; R01 HL037930/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
67763-96-6/Insulin-Like Growth Factor I; EC 2.7.10.1/Receptor, IGF Type 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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