Document Detail


Insulin-like growth factor 1 and growth hormone binding protein in depression: a preliminary communication.
MedLine Citation:
PMID:  10221744     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was undertaken in order to advance our understanding of the distal growth hormone axis in depression. Insulin-like growth factor 1 (IGF-1) and growth hormone binding protein (GHBP) were measured in a group of 19 depressed women and a group of 16 healthy women. Using a generalized linear model, IGF-1 levels were negatively correlated with age (p = 0.0001), influenced by menstrual phase (p = 0.016), and significantly increased in the depressed group (p = 0.02). Using the same type of analysis, GHBP was significantly related to menstrual phase (p = 0.0001) and body mass index (p = 0.0001), but was not significantly different in patients and controls. IGF-1 and GHBP were positively correlated among healthy subjects (r = 0.46, p = 0.08), but not among depressed patients (r = -0.16, p = 0.51), although these correlation coefficients were not statistically significantly different from each other. These findings confirm the importance of several physiological factors in the regulation of IGF-1 and GHBP, and suggest that depression further influences this regulation.
Authors:
B Franz; D J Buysse; C R Cherry; N S Gray; V J Grochocinski; E Frank; D J Kupfer
Related Documents :
7923964 - Long-term evolution and growth patterns in a family with bartter's syndrome.
7745234 - Serum soluble interleukin 2 (il-2) receptor (sil-2r) in differentiated thyroid carcinoma.
22879094 - White matter lesion progression in ladis: frequency, clinical effects, and sample size ...
22810444 - Adaptive bayesian randomized trials: realizing their potential.
10830464 - Cost analysis of the treatment of acute childhood lymphocytic leukaemia according to no...
24636204 - Gender differences in the relationship between physical functioning and depressive symp...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of psychiatric research     Volume:  33     ISSN:  0022-3956     ISO Abbreviation:  J Psychiatr Res     Publication Date:    1999 Mar-Apr
Date Detail:
Created Date:  1999-07-02     Completed Date:  1999-07-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376331     Medline TA:  J Psychiatr Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  121-7     Citation Subset:  IM    
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University, CA, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Body Mass Index
Carrier Proteins / metabolism*
Depressive Disorder / diagnosis,  metabolism*
Female
Humans
Insulin-Like Growth Factor I / metabolism*
Middle Aged
Obesity / diagnosis
Receptors, Somatotropin / metabolism*
Severity of Illness Index
Grant Support
ID/Acronym/Agency:
MH-24652/MH/NIMH NIH HHS; MH-30915/MH/NIMH NIH HHS; MH-49115/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Receptors, Somatotropin; 67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Prediction of hospitalizations by schizophrenia patients' assessment of treatment: an expanded study...
Next Document:  Neuropsychological assessments before and after treatment in patients with anorexia nervosa and buli...