Document Detail

Insulin-like growth factor 1 and growth hormone binding protein in depression: a preliminary communication.
MedLine Citation:
PMID:  10221744     Owner:  NLM     Status:  MEDLINE    
This study was undertaken in order to advance our understanding of the distal growth hormone axis in depression. Insulin-like growth factor 1 (IGF-1) and growth hormone binding protein (GHBP) were measured in a group of 19 depressed women and a group of 16 healthy women. Using a generalized linear model, IGF-1 levels were negatively correlated with age (p = 0.0001), influenced by menstrual phase (p = 0.016), and significantly increased in the depressed group (p = 0.02). Using the same type of analysis, GHBP was significantly related to menstrual phase (p = 0.0001) and body mass index (p = 0.0001), but was not significantly different in patients and controls. IGF-1 and GHBP were positively correlated among healthy subjects (r = 0.46, p = 0.08), but not among depressed patients (r = -0.16, p = 0.51), although these correlation coefficients were not statistically significantly different from each other. These findings confirm the importance of several physiological factors in the regulation of IGF-1 and GHBP, and suggest that depression further influences this regulation.
B Franz; D J Buysse; C R Cherry; N S Gray; V J Grochocinski; E Frank; D J Kupfer
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of psychiatric research     Volume:  33     ISSN:  0022-3956     ISO Abbreviation:  J Psychiatr Res     Publication Date:    1999 Mar-Apr
Date Detail:
Created Date:  1999-07-02     Completed Date:  1999-07-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376331     Medline TA:  J Psychiatr Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  121-7     Citation Subset:  IM    
Department of Psychiatry and Behavioral Sciences, Stanford University, CA, USA.
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MeSH Terms
Body Mass Index
Carrier Proteins / metabolism*
Depressive Disorder / diagnosis,  metabolism*
Insulin-Like Growth Factor I / metabolism*
Middle Aged
Obesity / diagnosis
Receptors, Somatotropin / metabolism*
Severity of Illness Index
Grant Support
Reg. No./Substance:
0/Carrier Proteins; 0/Receptors, Somatotropin; 67763-96-6/Insulin-Like Growth Factor I

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