| Insulin-like growth factor I and insulin and their abuse in sport. | |
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MedLine Citation:
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PMID: 20122448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is believed that insulin and insulin-like growth factor I (IGF-I) are abused by professional athletes, either alone or in combination with growth hormone (GH) and anabolic steroids. The recent introduction of IGF-I to clinical practice is likely to increase its availability and abuse. Insulin and IGF-I work together with GH to control the supply of nutrients to tissues in the fasted and fed state. The actions of insulin and IGF-I that may enhance performance include increased protein anabolism and glucose uptake and storage. The detection of IGF-I and insulin abuse is challenging. There are established mass spectrometry methods for insulin analogs. The feasibility of using GH-dependent markers to detect IGF-I use is being assessed. |
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Authors:
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Ioulietta Erotokritou-Mulligan; Richard I G Holt |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Endocrinology and metabolism clinics of North America Volume: 39 ISSN: 1558-4410 ISO Abbreviation: Endocrinol. Metab. Clin. North Am. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-04-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8800104 Medline TA: Endocrinol Metab Clin North Am Country: United States |
Other Details:
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Languages: eng Pagination: 33-43, viii Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Developmental Origins of Health and Disease Division, University of Southampton, School of Medicine, Southampton, Hampshire, UK. I.E.Mulligan@soton.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anabolic Agents Animals Athletic Performance / physiology Doping in Sports* / prevention & control Glucose / metabolism Humans Immunoassay Insulin / administration & dosage*, analysis, physiology Insulin-Like Growth Factor Binding Protein 3 / administration & dosage, adverse effects, analysis Insulin-Like Growth Factor I / administration & dosage*, adverse effects, analysis, physiology Intercellular Signaling Peptides and Proteins / administration & dosage, adverse effects, analysis Lipolysis / drug effects Protein Biosynthesis / drug effects Recombinant Proteins / administration & dosage, analysis |
| Chemical | |
Reg. No./Substance:
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0/Anabolic Agents; 0/IGF-I-IGFBP-3 complex; 0/Insulin-Like Growth Factor Binding Protein 3; 0/Intercellular Signaling Peptides and Proteins; 0/Recombinant Proteins; 0/myotrophin; 11061-68-0/Insulin; 50-99-7/Glucose; 67763-96-6/Insulin-Like Growth Factor I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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