| The insulin-like growth factor signaling pathway as a target for treatment of colorectal carcinoma. | |
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MedLine Citation:
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PMID: 20920993 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The insulin-like growth factors (IGFs), IGF1 and IGF2, are peptide hormones that bind to the insulin-like growth factor 1 receptor (IGF1R) and cause intracellular signaling that ultimately results in cellular growth and proliferation. Evidence from epidemiologic and preclinical studies suggests that IGF signaling may be of importance in the pathogenesis of colorectal cancer (CRC). In recent years, agents that target the IGF1R pathway have been developed. These agents are currently under evaluation for the treatment of CRC. |
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Authors:
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Gideon P Ewing; Laura W Goff |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical colorectal cancer Volume: 9 ISSN: 1938-0674 ISO Abbreviation: Clin Colorectal Cancer Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101120693 Medline TA: Clin Colorectal Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 219-23 Citation Subset: IM |
Affiliation:
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Department of Medicine, Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN, USA. gideon.ewing@vanderbilt.edu |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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