Document Detail


Insulin-like growth factor 2/H19 methylation at birth and risk of overweight and obesity in children.
MedLine Citation:
PMID:  22341586     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether aberrant DNA methylation at differentially methylated regions (DMRs) regulating insulin-like growth factor 2 (IGF2) expression in umbilical cord blood is associated with overweight or obesity in a multiethnic cohort.
STUDY DESIGN: Umbilical cord blood leukocytes of 204 infants born between 2005 and 2009 in Durham, North Carolina, were analyzed for DNA methylation at two IGF2 DMRs by using pyrosequencing. Anthropometric and feeding data were collected at age 1 year. Methylation differences were compared between children >85th percentile of the Centers for Disease Control and Prevention growth charts weight-for-age (WFA) and children ≤ 85th percentile of WFA at 1 year by using generalized linear models, adjusting for post-natal caloric intake, maternal cigarette smoking, and race/ethnicity.
RESULTS: The methylation percentages at the H19 imprint center DMR was higher in infants with WFA >85th percentile (62.7%; 95% CI, 59.9%-65.5%) than in infants with WFA ≤ 85th percentile (59.3%; 95% CI, 58.2%-60.3%; P = .02). At the intragenic IGF2 DMR, methylation levels were comparable between infants with WFA ≤ 85th percentile and infants with WFA >85th percentile.
CONCLUSIONS: Our findings suggest that IGF2 plasticity may be mechanistically important in early childhood overweight or obese status. If confirmed in larger studies, these findings suggest aberrant DNA methylation at sequences regulating imprinted genes may be useful identifiers of children at risk for the development of early obesity.
Authors:
Ellen Perkins; Susan K Murphy; Amy P Murtha; Joellen Schildkraut; Randy L Jirtle; Wendy Demark-Wahnefried; Michele R Forman; Joanne Kurtzberg; Francine Overcash; Zhiqing Huang; Cathrine Hoyo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-02-17
Journal Detail:
Title:  The Journal of pediatrics     Volume:  161     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-25     Completed Date:  2012-09-10     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  31-9     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Mosby, Inc. All rights reserved.
Affiliation:
Department of Community and Family Medicine, Duke University, Durham, NC 27710, USA.
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MeSH Terms
Descriptor/Qualifier:
DNA Methylation*
Female
Humans
Infant
Insulin-Like Growth Factor II / genetics*
Male
Obesity / genetics*
Overweight / genetics*
Prospective Studies
Risk
Grant Support
ID/Acronym/Agency:
ES016772/ES/NIEHS NIH HHS; K01 CA104517-05/CA/NCI NIH HHS; K01CA104517/CA/NCI NIH HHS; R01 DK085173/DK/NIDDK NIH HHS; R01 DK085173-02/DK/NIDDK NIH HHS; R01 ES015165/ES/NIEHS NIH HHS; R01 ES016772-01A1/ES/NIEHS NIH HHS; R01DK085173/DK/NIDDK NIH HHS; R21 ES014947-02/ES/NIEHS NIH HHS; R21ES014947/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
67763-97-7/Insulin-Like Growth Factor II
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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