Document Detail


Insulin improves contractile function during moderate ischemia in canine left ventricle.
MedLine Citation:
PMID:  9612366     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study determined the effects of insulin on myocardial contractile function and glucose metabolism during moderate coronary hypoperfusion. Coronary perfusion pressure (CPP) was lowered from 100 to 60, 50, and 40 mmHg in the left anterior descending coronary artery of anesthetized, open-chest dogs. Regional glucose uptake (GU), lactate uptake, myocardial O2 consumption, and percent segment shortening (%SS) were measured without (n = 12) or with intravenous (4 U/min, n = 12) or intracoronary insulin (4 U/min, n = 6). Glucose metabolites were also measured in freeze-clamped biopsies of control heart (n = 6) and hearts treated with intravenous insulin (n = 6) at the completion of the protocol (40 mmHg CPP). GU increased with intravenous and intracoronary insulin (P < 0.01). In all groups, GU was unaffected by reduced CPP, although lactate uptake decreased significantly (P < 0.01). Myocardial O2 consumption fell (P < 0.05) as CPP was lowered in all groups and was not altered significantly by intravenous or intracoronary insulin treatment. Without insulin, %SS decreased 72% (P < 0.05) at 40 mmHg CPP, but in hearts treated with intravenous and intracoronary insulin, %SS was not reduced (P > 0.05). Myocardial glycogen, alanine, lactate, and pyruvate contents were not significantly different in untreated hearts and hearts treated with intravenous insulin. Thus, in moderately ischemic canine myocardium, insulin markedly improved regional contractile function and did not appreciably increase the products of anaerobic glucose metabolism.
Authors:
J D Tune; R T Mallet; H F Downey
Related Documents :
20626226 - Biophysical investigation on left ventricular myocytes in rats with experimentally indu...
12955406 - Insulin addition after ischemia improves recovery of function equal to ischemic precond...
12441406 - Upregulation of pkc genes and isozymes in cardiovascular tissues during early stages of...
2763226 - Ventilatory and heart rate responses to hypoxia and hypercapnia in patients with diabet...
7606286 - Delusional misidentification and subsequent dementia: a clinical and neuropathological ...
6893466 - An investigation of pyruvate metabolism in patients with cerebellar and spinocerebellar...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  274     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-06-24     Completed Date:  1998-06-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1574-81     Citation Subset:  IM    
Affiliation:
Department of Integrative Physiology, University of North Texas Health Science Center at Fort Worth 76107-2699, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Dogs
Glucose / physiology
Heart Ventricles / drug effects,  physiopathology*
Insulin / pharmacology*,  therapeutic use
Myocardial Contraction / drug effects*
Myocardial Ischemia / drug therapy*,  physiopathology*
Ventricular Function, Left / drug effects
Grant Support
ID/Acronym/Agency:
HL-35027/HL/NHLBI NIH HHS; HL-50441/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
11061-68-0/Insulin; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Upregulation of the cardiac homeobox gene Nkx2-5 (CSX) in feline right ventricular pressure overload...
Next Document:  Cholinergic nerve function in monkey ciliary arteries innervated by nitroxidergic nerve.