| Insulin glargine: Use during pregnancy. | |
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MedLine Citation:
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PMID: 21613047 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: Review the literature regarding the use of insulin glargine during pregnancy, specifically addressing the issues/concerns regarding mitogenicity, placental transfer, and maternal and fetal safety.Methods: A systematic literature search was conducted using MEDLINE and BIOSIS Previews. Additional studies were identified by hand-searching reference lists from original articles.Results: Insulin glargine does not appear to have enhanced mitogenic activity when compared to native human insulin. In addition, the trans-placental transfer of insulin glargine appears to be negligible, although it is possible that antibody-bound insulin glargine may gain access to the fetal compartment. The available data suggest that there are no identifiable, consistent adverse maternal or fetal outcomes obtained with the use of insulin glargine during pregnancy, including the 1st trimester.Conclusion: The use of insulin glargine during pregnancy should be seriously considered in uncontrolled diabetes during pregnancy and in those patients taking insulin glargine prior to conception, since the benefits from improved glycemic control would be expected to outweigh any, as yet, unproven risks of insulin glargine exposure. |
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Authors:
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Kevin M Pantalone; Charles Faiman; Leann Olansky |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-25 |
Journal Detail:
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Title: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists Volume: - ISSN: 1934-2403 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9607439 Medline TA: Endocr Pract Country: - |
Other Details:
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Languages: ENG Pagination: 1-25 Citation Subset: - |
Affiliation:
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Endocrinology and Metabolism Institute, Cleveland Clinic, Cleveland, Ohio. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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