| Insulin detemir for the treatment of obese patients with type 2 diabetes. | |
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MedLine Citation:
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PMID: 22291472 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The risk for developing type 2 diabetes (T2DM) is greater among obese individuals. Following onset of the disease, patients with T2DM become more likely to be afflicted with diabetic micro- and macrovascular complications. Decreasing body weight has been shown to lower glycosylated hemoglobin and improve other metabolic parameters in patients with T2DM. Medications used to lower blood glucose may increase body weight in patients with T2DM and this has been repeatedly shown to be the case for conventional, human insulin formulations. Insulin detemir is a neutral, soluble, long-acting insulin analog in which threonine-30 of the insulin B-chain is deleted, and the C-terminal lysine is acetylated with myristic acid, a C14 fatty acid chain. Insulin detemir binds to albumin, a property that enhances its pharmacokinetic/pharmacodynamic profile. Results from clinical trials have demonstrated that treatment with insulin detemir is associated with less weight gain than either insulin glargine or neutral protamine Hagedorn insulin. There are many potential reasons for the lower weight gain observed among patients treated with insulin detemir, including lower risk for hypoglycemia and therefore decreased defensive eating due to concern about this adverse event, along with other effects that may be related to the albumin binding of this insulin that may account for lower within-patient variability and consistent action. These might include faster transport across the blood-brain barrier, induction of satiety signaling in the brain, and preferential inhibition of hepatic glucose production versus peripheral glucose uptake. Experiments in diabetic rats have also indicated that insulin detemir increases adiponectin levels, which is associated with both weight loss and decreased eating. |
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Authors:
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Priscilla A Hollander |
Publication Detail:
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Type: Journal Article Date: 2012-01-10 |
Journal Detail:
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Title: Diabetes, metabolic syndrome and obesity : targets and therapy Volume: 5 ISSN: 1178-7007 ISO Abbreviation: Diabetes Metab Syndr Obes Publication Date: 2012 |
Date Detail:
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Created Date: 2012-01-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101515585 Medline TA: Diabetes Metab Syndr Obes Country: New Zealand |
Other Details:
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Languages: eng Pagination: 11-9 Citation Subset: - |
Affiliation:
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Baylor Endocrine Center, Dallas, Texas, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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