Document Detail

Insulin changes in preeclamptic women during pregnancy.
MedLine Citation:
PMID:  15646160     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The etiology of preeclampsia remains obscure. To study the role of insulin resistance in preeclampsia, we compared fasting insulin and glucose changes during the second and third trimesters in preeclamptic women with a normal control group. PATIENTS AND METHODS: In a nested case-control study, subjects were selected from a population-based cohort of 674 pregnant women from whom serum was collected for this study between the 20th and 24th week of gestation. For 16 women who developed preeclampsia (cases), 16 women who remained normotensive were selected as controls. Controls were matched with each case for pregestational body mass index, age, gestational age, and parity. Fasting glucose and insulin levels of the second trimester (20th to 24th weeks) of pregnancy were compared based on serological data. The comparisons were also carried out in the third trimester when preeclampsia occurred. RESULTS: Fasting insulin levels increased from 15.3+/-1.3 microlU/mL to 25.3+/-1.4 microlU/mL between the second and third trimesters in the preeclamptic group (P<0.01) and from 10.4+/-0.9 microlU/mL to 16.2+/-1.3 microlU/mL in the control group (P<0.01). There was no significant change in glucose levels during pregnancy in either group. CONCLUSION: Women who develop preeclampsia have higher insulin levels before clinical evidence of disease than women who remain normotensive during pregnancy. The increase in insulin levels in the third trimester was greater in preeclamptic than in non-preeclamptic women.
Shohreh Malek-Khosravi; Bijan Kaboudi
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of Saudi medicine     Volume:  24     ISSN:  0256-4947     ISO Abbreviation:  Ann Saudi Med     Publication Date:    2004 Nov-Dec
Date Detail:
Created Date:  2005-01-13     Completed Date:  2005-03-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8507355     Medline TA:  Ann Saudi Med     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  434-6     Citation Subset:  IM    
Obstetrics & Gynecology Department, Motazedi Hospital, Kermanshah, Iran.
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MeSH Terms
Blood Glucose / analysis
Case-Control Studies
Insulin / blood*
Pre-Eclampsia / blood*
Pregnancy Trimester, Third
Pregnancy Trimesters
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin

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