Document Detail

Insulin, but not estrogen, correlated with indexes of desaturase function in obese women.
MedLine Citation:
PMID:  7642175     Owner:  NLM     Status:  MEDLINE    
This study determined the associations of serum insulin and estrogen with fatty acid composition, fatty acid product/substrate ratios used as indexes of desaturase enzyme function, and platelet aggregation in obese and lean women. Thirty women were classified as obese (n = 8) or lean (n = 21) based on body mass index. Obese women were characterized by higher insulin levels (p < 0.05) but fasting glucose levels did not differ (p > 0.05) from lean women. Insulin positively correlated with increased C20:4n6/C18:3n6 (index of delta 5-desaturase) (p < 0.05) and C20:4n6/C18:2n6 (index of overall n6 pathway activity) (p < 0.01) in serum, and the n5 pathway in platelets (p < 0.01), but there was no correlation for insulin with platelet C18:3n6/C18:2n6 (index of delta 6-desaturase activity). Insulin was also positively related (p < 0.01) to aggregation as measured by impedance and negatively related to lag time (p < 0.05). Platelets of obese women aggregated more (p < 0.05) compared to lean women and began aggregating faster (p < 0.05), suggesting the possibility that the obese women were at greater risk for enhanced blood clotting. Plasma estrogen was correlated with age (p < 0.05) but not for other variables studied (p > 0.05). Insulin, but not estrogen, appears to influence desaturase activity, as demonstrated by increased desaturase function associated with hyperinsulinemia in obese women.
L C Medeiros; Y W Liu; S Park; P H Chang; A M Smith
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  27     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-09-21     Completed Date:  1995-09-21     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  235-8     Citation Subset:  IM    
Department of Human Nutrition and Food Management, Ohio State University, Columbus, USA.
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MeSH Terms
Blood Glucose / analysis
Estrogens / blood*
Fatty Acid Desaturases / physiology*
Insulin / blood*
Middle Aged
Obesity / blood*
Phospholipids / blood
Reg. No./Substance:
0/Blood Glucose; 0/Estrogens; 0/Phospholipids; 11061-68-0/Insulin; EC 1.14.19.-/Fatty Acid Desaturases

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