Document Detail

Insulin as a pressor agent: effects of 'physiological' insulin concentrations on finger blood pressure.
MedLine Citation:
PMID:  9162432     Owner:  NLM     Status:  MEDLINE    
Epidemiological evidence has linked essential hypertension with impaired tissue sensitivity to insulin (i.e. insulin resistance) and actions which could contribute to elevated blood pressure include renal sodium and water retention, sympathetic nervous system stimulation and effects on vascular smooth muscle cell growth and cation balance. Although insulin has pressor effects in some animal models, similar changes in human studies have only been demonstrable with supraphysiological insulin concentrations. We have recently measured finger blood pressure during a two stage hyperinsulinaemic euglycaemic clamp that produced insulin concentrations within the 'physiological' range. The plasma insulin concentration increased from 7.0 +/- 0.3 mu to 28.9 +/- 0.6 mu then to 101 +/-1.7 mu during the procedure and was associated with an increase in fingers but not arm systolic blood pressure during both low dose (i.e.+ 9.9 +/- 1.9 mmHg vs + 7.5 +/- 2.7 mmHg with control,p <0.05) and high dose insulin (21.9 +/- 2.3 mmHg vs 14.6 +/- 3.1 mmHg, p <0.01). Thus it appears that 'physiological' concentrations of insulin have pressor effects on finger systolic blood pressure that are not detectable more proximally and it is possible that such changes could contribute to the development of sustained elevations of blood pressure.
C J O'Callaghan; K Komersova; W J Louis
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Blood pressure. Supplement     Volume:  1     ISSN:  0803-8023     ISO Abbreviation:  Blood Press Suppl     Publication Date:  1996  
Date Detail:
Created Date:  1997-05-27     Completed Date:  1997-05-27     Revised Date:  2008-02-26    
Medline Journal Info:
Nlm Unique ID:  9300787     Medline TA:  Blood Press Suppl     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  18-22     Citation Subset:  IM    
Department of Clinical Pharmacology and Therapeutics, University of Melbourne, Victoria, Australia.
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MeSH Terms
Blood Pressure / physiology*
Cross-Over Studies
Fingers / blood supply*
Hyperinsulinism / physiopathology
Hypertension / etiology,  physiopathology
Insulin / blood,  physiology*
Insulin Resistance / physiology
Single-Blind Method
Reg. No./Substance:

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