| Insulin allergy. | |
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MedLine Citation:
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PMID: 21496738 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Insulin reactions occur rarely but are of tremendous clinical importance. The first was reported in 1922 as a callus reaction at the injection site of insufficiently purified bovine insulin. Porcine insulin was subsequently found to be less allergenic than bovine insulin. Increasingly pure insulins have decreased the risk of adverse reactions, and the production of recombinant insulin with the same amino sequence as human insulin saw a large decrease in adverse reactions. Currently, the prevalence of allergic reactions to insulin products appears to be approximately 2%, and less than one-third of these events have been considered related to the insulin itself. Other reactions occur due to the preservatives added to insulin, including zinc, protamine, and meta-cresol. Allergic reactions can be type I or immunoglobulin E-mediated, type III or Arthus, and type IV or delayed-type hypersensitivity reactions. Type I reactions are the most common and can, rarely, cause anaphylaxis. In contrast, type IV reactions can occur after a delay of several days. Investigations include skin prick testing, patch testing, intradermal testing, and occasionally, skin biopsy. |
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Authors:
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Mohammad K Ghazavi; Graham A Johnston |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinics in dermatology Volume: 29 ISSN: 1879-1131 ISO Abbreviation: Clin. Dermatol. Publication Date: 2011 May-Jun |
Date Detail:
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Created Date: 2011-04-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8406412 Medline TA: Clin Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 300-5 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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