| Insulin Sensitivity and Liver Fat: Role of Iron Load. | |
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MedLine Citation:
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PMID: 21430023 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Context: Increased liver fat (LF) is associated with insulin resistance. However, a considerable individual variability between LF and insulin sensitivity (IS) is observed, and at equal levels of LF, insulin-resistant as well as insulin-sensitive individuals are found. Objective: Our objective was to study whether hepatic iron load (HIL) explains some of the variation between IS and LF. Design: HIL was measured using a quantitative T2* magnetic resonance gradient echo imaging technique, and LF was measured by (1)H-magnetic resonance spectroscopy. Low T2* values indicate high HIL. We studied the association of LF and HIL with anthropometric data and IS. A total of 113 healthy nondiabetic subjects [69 females, 44 males; age 47 ± 1 yr; body mass index (BMI) = 28.9 ± 0.5 kg/m(2)] at increased risk for type 2 diabetes were included in the study. Results: T2* values adjusted for age negatively associated with serum ferritin levels (P < 0.0001) and positively associated with IS (P = 0.009). In addition, T2* values associated with LF (P = 0.008) but not with BMI (P = 0.6). In a multivariate model, IS adjusted for gender, age, and BMI was associated with T2* values (P = 0.015). IS adjusted for gender and age was independently associated with LF (P = 0.033) and T2* values (P = 0.004). In a stepwise regression analysis, LF explained 13.5% (P < 0.01) of the variation in IS, and HIL explained an additional 4.1% (P = 0.03). Conclusions: HIL explains part of the variation between LF and IS. The mechanism by which iron load induces insulin resistance is possibly independent of the pathways involved in insulin resistance induced by fatty liver disease. |
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Authors:
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Michael Haap; Jürgen Machann; Christine von Friedeburg; Fritz Schick; Norbert Stefan; Nina F Schwenzer; Andreas Fritsche; Hans Ulrich Häring; Claus Thamer |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-23 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: - ISSN: 1945-7197 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Internal Medicine (M.H., C.v.F., N.S., A.F., H.U.H., C.T.), Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, and Section on Experimental Radiology (J.M., F.S., N.F.S.), Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University Tübingen, D-72076 Tübingen, Germany. |
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