Document Detail

Insulin resistance and prevalence of prehypertension and hypertension among community-dwelling persons.
MedLine Citation:
PMID:  20145357     Owner:  NLM     Status:  MEDLINE    
AIM: There are few data focusing on the effect of insulin resistance on a new risk category of prehypertension (120-139 mmHg systolic and/or 80-89 mmHg diastolic blood pressure) recently established by The Seventh Report of the Joint National Committee on High Blood Pressure (JNC-7). We aimed to determine whether insulin resistance was associated with a risk for prehypertension and hypertension. METHODS: Of 3,164 (34.6% of 9,133 adults aged 19 to 90 years) adults at the community-based annual medical check-up, study participants without a clinical history of stroke, transient ischemic attack, myocardial infarction, angina, or renal failure (567 men aged 57+/-14 (mean+/-standard deviation); range, 20-84) years and 702 women aged 59+/-12; 21-88 years) were recruited. We examined the cross-sectional relationship between insulin resistance, which was evaluated by homeostasis of minimal assessment of insulin resistance (HOMA-IR) and normotension, prehypertension, or hyper-tension using the JNC-7 criteria. RESULTS: The HOMA-IR correlated significantly with systolic (r=0.171) and diastolic (r=0.170) blood pressures. Triglycerides >or=150 mg/dL, HDL-C <40 mg/dL, metabolic syndrome, serum uric acid >or=7.0 mg/dL, and HOMA-IR >or=2.5 showed the highest crude odds ratio (OR) for progression from normotension to prehypertension, and >or=65 years, FBG >or=110 mg/dL, metabolic syndrome, and HOMA-IR >or=2.5 showed the highest crude OR for progression from normotension to hypertension. Multivariate logistic regression analysis showed that HOMA-IR was independently associated with the presence of prehypertension and hypertension. CONCLUSIONS: Insulin resistance was significantly associated with prehypertension as well as hypertension in the general population.
Ryuichi Kawamoto; Katsuhiko Kohara; Yasuharu Tabara; Masanori Abe; Tomo Kusunoki; Tetsuro Miki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-10
Journal Detail:
Title:  Journal of atherosclerosis and thrombosis     Volume:  17     ISSN:  1880-3873     ISO Abbreviation:  J. Atheroscler. Thromb.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-26     Completed Date:  2010-05-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506298     Medline TA:  J Atheroscler Thromb     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  148-55     Citation Subset:  IM    
Department of Community Medicine, Ehime University Graduate School of Medicine, Ehime, Japan.
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MeSH Terms
Aged, 80 and over
Blood Pressure
Body Mass Index
Hypertension / epidemiology,  metabolism,  pathology*
Insulin Resistance*
Metabolic Syndrome X / metabolism
Middle Aged
Odds Ratio
Risk Factors

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