| Insulin resistance and prevalence of prehypertension and hypertension among community-dwelling persons. | |
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MedLine Citation:
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PMID: 20145357 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: There are few data focusing on the effect of insulin resistance on a new risk category of prehypertension (120-139 mmHg systolic and/or 80-89 mmHg diastolic blood pressure) recently established by The Seventh Report of the Joint National Committee on High Blood Pressure (JNC-7). We aimed to determine whether insulin resistance was associated with a risk for prehypertension and hypertension. METHODS: Of 3,164 (34.6% of 9,133 adults aged 19 to 90 years) adults at the community-based annual medical check-up, study participants without a clinical history of stroke, transient ischemic attack, myocardial infarction, angina, or renal failure (567 men aged 57+/-14 (mean+/-standard deviation); range, 20-84) years and 702 women aged 59+/-12; 21-88 years) were recruited. We examined the cross-sectional relationship between insulin resistance, which was evaluated by homeostasis of minimal assessment of insulin resistance (HOMA-IR) and normotension, prehypertension, or hyper-tension using the JNC-7 criteria. RESULTS: The HOMA-IR correlated significantly with systolic (r=0.171) and diastolic (r=0.170) blood pressures. Triglycerides >or=150 mg/dL, HDL-C <40 mg/dL, metabolic syndrome, serum uric acid >or=7.0 mg/dL, and HOMA-IR >or=2.5 showed the highest crude odds ratio (OR) for progression from normotension to prehypertension, and >or=65 years, FBG >or=110 mg/dL, metabolic syndrome, and HOMA-IR >or=2.5 showed the highest crude OR for progression from normotension to hypertension. Multivariate logistic regression analysis showed that HOMA-IR was independently associated with the presence of prehypertension and hypertension. CONCLUSIONS: Insulin resistance was significantly associated with prehypertension as well as hypertension in the general population. |
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Authors:
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Ryuichi Kawamoto; Katsuhiko Kohara; Yasuharu Tabara; Masanori Abe; Tomo Kusunoki; Tetsuro Miki |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-10 |
Journal Detail:
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Title: Journal of atherosclerosis and thrombosis Volume: 17 ISSN: 1880-3873 ISO Abbreviation: J. Atheroscler. Thromb. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-26 Completed Date: 2010-05-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9506298 Medline TA: J Atheroscler Thromb Country: Japan |
Other Details:
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Languages: eng Pagination: 148-55 Citation Subset: IM |
Affiliation:
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Department of Community Medicine, Ehime University Graduate School of Medicine, Ehime, Japan. rykawamo@ehime.med.or.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Blood Pressure Body Mass Index Female Humans Hypertension / epidemiology, metabolism, pathology* Insulin Resistance* Male Metabolic Syndrome X / metabolism Middle Aged Odds Ratio Risk Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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