| Insulin- and Obesity-Related Variables in Early-Stage Breast Cancer: Correlations and Time Course of Prognostic Associations. | |
| | |
MedLine Citation:
|
PMID: 22162568 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
PURPOSETo investigate patterns of prognostic associations over time of insulin- and obesity-related variables measured at diagnosis of early breast cancer (BC), focusing on whether the prognostic associations with distant recurrence and death changed over time. PATIENTS AND METHODSFive hundred thirty-five nondiabetic women with T1-3, N0-1, M0 invasive BC diagnosed from 1989 to 1996 were included in the study. Insulin-related variables included fasting insulin, Homeostasis Model Assessment, C-peptide, and glucose. Obesity-related variables included weight, body mass index (BMI), waist and hip circumference, and leptin. Correlations were examined using the Pearson correlation coefficient and prognostic associations using the Cox model. RESULTS: hazard ratio [HR], 2.32; 95% CI, 1.39 to 3.86; P < .001 for distant disease-free survival [DDFS]; and HR, 2.85; 95% CI, 1.48 to 5.50; P = .002 for overall survival [OS], with little attenuation of this pattern in multivariable analyses). In contrast, obesity-related variables (BMI, weight, leptin) exerted significant adverse univariable associations that were constant over time (eg, BMI quartile 4 v 2: HR, 1.40; 95% CI, 1.07 to 1.82 for DDFS; P = .014; and HR, 1.50; 95% CI, 1.16 to 1.93; P < .001 for OS); prognostic associations of leptin remained significant in multivariable analyses. CONCLUSIONBaseline insulin- and obesity-related variables exert different patterns of prognostic associations over time in early BC. |
| | |
Authors:
|
Pamela J Goodwin; Marguerite Ennis; Kathleen I Pritchard; Maureen E Trudeau; Jarley Koo; Sara K Taylor; Nicky Hood |
Related Documents
:
|
21416148 - No signs of progressive beta cell damage during 20 years of prospective follow-up of a... 7011508 - The effect of rectal administration of insulin on the short-term treatment of alloxan-d... 1826248 - Deterioration in blood glucose control in females with diabetes changed to a basal-bolu... 10600908 - Energetic dependence of npy-induced lh secretion in a teleost fish (dicentrarchus labrax). 1521978 - Prevalence of diagnosed diabetes in circumpolar indigenous populations. 10329478 - Glucose signaling in yeast is partially mimicked by galactose and does not require the ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-12 |
Journal Detail:
|
Title: Journal of clinical oncology : official journal of the American Society of Clinical Oncology Volume: - ISSN: 1527-7755 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8309333 Medline TA: J Clin Oncol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Pamela J. Goodwin, Mount Sinai Hospital and Princess Margaret Hospital, University of Toronto; Kathleen I. Pritchard and Maureen E. Trudeau, Sunnybrook Odette Cancer Centre, University of Toronto; Jarley Koo, St Michael's Hospital, University of Toronto; Nicky Hood, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto; Marguerite Ennis, Applied Statistician, Markham, Ontario; and Sara K. Taylor, British Columbia Cancer Agency, Kelowna, British Columbia, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Congenital Anomalies in the Children of Cancer Survivors: A Report From the Childhood Cancer Survivo...
Next Document: Treatment of Colorectal Peritoneal Carcinomatosis With Systemic Chemotherapy: A Pooled Analysis of N...