| Insulin-Like Growth Factor-I, Inflammatory Proteins, and Fibrosis in Subjects With Nonalcoholic Fatty Liver Disease. | |
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MedLine Citation:
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PMID: 23316084 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Context:Inflammation may have a pathogenic role in the progression of nonalcoholic fatty liver disease (NAFLD); by contrast, the role of anti-inflammatory molecules has not been addressed. Low circulating levels of the anti-inflammatory molecule IGF-I have been described in subjects with NAFLD.Objective:The aim of the study was to elucidate the clinical significance of IGF-I in NAFLD and its relationship with inflammatory biomarkers and fibrosis.Design and Setting:We conducted a cross-sectional study and in vitro experiments on hepatic HepG2 cells at the Internal Medicine and Gastrointestinal and Liver Units of the Universities of Catanzaro and Palermo.Subjects:A total of 221 individuals with NAFLD diagnosed on ultrasonography (cohort 1) and 50 subjects with biopsy-proven NAFLD (cohort 2) participated in the study.Intervention:Liver ultrasonography was performed on cohort 1, and hepatic biopsies were obtained from cohort 2.Main Outcome Measures:NAFLD fibrosis and Kleiner scores were calculated. IGF-I and inflammatory biomarker plasma concentrations were assessed with specific assays. In the in vitro study, real-time RT-PCR was used to assess the mRNA expression levels of acute-phase reactants.Results:In the first cohort, circulating IGF-I levels showed an inverse correlation with NAFLD fibrosis score and inflammatory biomarkers; similarly in the second cohort, liver IGF-I mRNA levels and the fibrosis score showed a negative relationship. Finally, we showed that IGF-I was able to directly modulate the expression of acute-phase reactants, decreasing C-reactive protein and fibrinogen levels and up-regulating albumin expression in HepG2 cells.Conclusions:The present data suggest that evaluation of circulating IGF-I and proinflammatory markers might be useful to assess comprehensively the severity of the disease in individuals with NAFLD. |
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Authors:
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Marta Letizia Hribal; Teresa Procopio; Salvatore Petta; Angela Sciacqua; Stefania Grimaudo; Rosaria Maria Pipitone; Francesco Perticone; Giorgio Sesti |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-11 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: - ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Medical and Surgical Sciences (M.L.H., T.P., A.S., F.P., G.S.), Viale Europa, University Magna-Graecia of Catanzaro, 88100 Catanzaro, Italy; and Gastroenterology Unit (S.P., S.G., R.M.P.), Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, 90127 Palermo, Italy. |
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