| Insulin and IGF-1 receptors, nitrotyrosin and cerebral neuronal deficits in two young patients with diabetic ketoacidosis and fatal brain edema. | |
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MedLine Citation:
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PMID: 20420811 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Gray and white matter structural deficits may accompany type 1 diabetes. Earlier experimental studies have demonstrated neuronal deficits associated with impaired neurotrophic support, inflammation and oxidative stress. In this study we demonstrate in two patients with histories of poorly controlled type 1 diabetes and fatal brain edema of ketoacidosis neuronal deficits associated with a decreased presence of insulin and IGF-1 receptors and accumulation of nitrotyrosin in neurons of affected areas and the choroid plexus. The findings add support to the suggested genesis of T1DM encephalopathy due to compromised neurotrophic protection, oxidative stress, inflammation and neuronal deficits, as demonstrated in T1DM encephalopathy in the BB/Wor-rat. |
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Authors:
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William H Hoffman; Anuska V Andjelkovic; Weixian Zhang; Gregory G Passmore; Anders A F Sima |
Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-24 |
Journal Detail:
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Title: Brain research Volume: 1343 ISSN: 1872-6240 ISO Abbreviation: Brain Res. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 168-77 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010. Published by Elsevier B.V. |
Affiliation:
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Department of Pediatrics, Section of Pediatric Endocrinology, Medical College of Georgia, Augusta, GA, USA. whoffman@mail.mcg.edu |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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