| Insulin Glargine or NPH in Patients with Severe Insulin Resistance: Is there a Benefit? | |
| | |
MedLine Citation:
|
PMID: 22232027 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Objective: To report the benefit of NPH insulin compared to insulin glargine in a patient with type 2 diabetes associated with severe insulin resistance.Methods: We describe a 52-year-old male with 3-year history of type 2 diabetes who failed to achieve adequate glucose control, despite escalating his regimen of insulin glargine to 80 units twice a day with insulin lispro 60 units before each meal, in addition to metformin.Results: Dietary and lifestyle changes were emphasized and implemented while medication adherence with appropriate insulin technique was reviewed at each visit. The decision was made to replace insulin glargine with the same dose of NPH insulin. After 3 months, a significant drop in HbA1c was noted, from 9.5 to 6.1%, consistent with the improved capillary glucose measurements. The effect was maintained over the following year, without any major hypoglycemic events.Conclusion: NPH insulin might be superior to the long acting analogue glargine in cases of severe insulin resistance, but randomized studies are needed to confirm our finding and clarify the involved mechanisms. |
| | |
Authors:
|
Vasile M Bota; Irl B Hirsch |
Related Documents
:
|
16202847 - The g-308a promoter variant of the tumor necrosis factor-alpha gene is associated with ... 20395227 - Metabolic syndrome exacerbating ankle-brachial index in asian type 2 diabetic patients. 19226407 - Hypogonadism, ed, metabolic syndrome and obesity: a pathological link supporting cardio... 21923457 - Safety and effectiveness of u-500 insulin therapy in patients with insulin-resistant ty... 18000317 - "i take what i think works for me": a qualitative study to explore patient perception o... 5046507 - Observations on blood glucose and insulin determinations. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-9 |
Journal Detail:
|
Title: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists Volume: - ISSN: 1934-2403 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9607439 Medline TA: Endocr Pract Country: - |
Other Details:
|
Languages: ENG Pagination: 1-9 Citation Subset: - |
Affiliation:
|
Roger Williams Medical Center, Boston University School of Medicine, Providence, RI. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Primary Hyperparathyroidism and FHH: Relationships and Clinical Implications.
Next Document: Effect of Hospital Admission on Glycemic Control One Year after Discharge.