| Insulin detemir is not transported across the blood-brain barrier. | |
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MedLine Citation:
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PMID: 20868713 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Insulin detemir has a different profile of action on the central nervous system (CNS) than human insulin. It has been hypothesized that this is caused by an altered ability of insulin detemir to cross the blood-brain barrier (BBB). Here, we measured the permeability of the BBB to insulin detemir. We labeled insulin detemir with radioactive iodine (I-Det) and examined its ability to cross the BBB of the mouse. Permeation was assessed after intravenous injection and by brain perfusion in the presence or absence of excess insulin detemir. The ability of insulin detemir to inhibit human insulin transport across the BBB was also assessed. I-Det did not cross the BBB either after intravenous injection or when studied by brain perfusion, a method which removes or reduces the influence of circulating proteins. Unlabeled detemir was about 10 times less potent than human insulin at inhibiting the transport of radioactive human insulin across the BBB. The altered CNS profile of insulin detemir may be caused by its poor access to CNS receptors and by a block of human insulin from crossing the BBB. |
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Authors:
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William A Banks; John E Morley; Jessica L Lynch; Kristin M Lynch; Arshag D Mooradian |
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Publication Detail:
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Type: Journal Article Date: 2010-09-22 |
Journal Detail:
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Title: Peptides Volume: 31 ISSN: 1873-5169 ISO Abbreviation: Peptides Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-01 Completed Date: 2011-02-10 Revised Date: 2012-01-11 |
Medline Journal Info:
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Nlm Unique ID: 8008690 Medline TA: Peptides Country: United States |
Other Details:
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Languages: eng Pagination: 2284-8 Citation Subset: IM |
Copyright Information:
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Published by Elsevier Inc. |
Affiliation:
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GRECC, Veterans Affairs Puget Sound Health Care System, United States. wabanks1@u.washington.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport / physiology* Blood-Brain Barrier / metabolism* Brain / metabolism Insulin / analogs & derivatives*, pharmacokinetics Insulin, Long-Acting Male Mice Mice, Inbred ICR |
| Grant Support | |
ID/Acronym/Agency:
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R01 AG029839-02/AG/NIA NIH HHS; R01 AG029839-05/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Insulin; 0/Insulin, Long-Acting; 0/insulin detemir |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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