| Insulin and C-peptide secretion in non-obese patients with polycystic ovarian disease. | |
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MedLine Citation:
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PMID: 2684835 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plasma glucose, immunoreactive insulin (IRI) and C-peptide responses during an oral glucose tolerance test (oGTT) were assessed in 11 non-obese patients with polycystic ovarian disease (PCOD) and 11 reference subjects matched for age, height and weight. Also, 6 patients with PCOD and 6 normal women were subjected to intravenous glucose tolerance testing (ivGTT) On oGTT, all subjects exhibited normal glucose tolerance; however, PCOD patients had significantly higher mean plasma glucose levels at 30, 60, 90 and 120 min and higher mean incremental glucose areas. In addition the patients with polycystic ovaries showed higher mean basal IRI and C-peptide levels, higher mean glucose stimulated IRI and C-peptide levels and higher mean incremental IRI and C-peptide values. The molar ratios of C-peptide/IRI were significantly lower in the PCOD group at all time intervals after glucose stimulation when compared to the normal women. During ivGTT, there were significantly higher mean glucose levels at 5, 40, 50 and 60 min in the PCOD group when compared to the reference group. The IRI response to intravenous glucose in the PCOD women was similar to the reference group. The findings on oGTT suggest that non-obese patients with PCOD have increased pancreatic IRI secretion as well as impaired hepatic extraction of the hormone. |
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Authors:
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S Mahabeer; I Jialal; R J Norman; C Naidoo; K Reddi; S M Joubert |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme Volume: 21 ISSN: 0018-5043 ISO Abbreviation: Horm. Metab. Res. Publication Date: 1989 Sep |
Date Detail:
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Created Date: 1990-01-11 Completed Date: 1990-01-11 Revised Date: 2009-02-19 |
Medline Journal Info:
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Nlm Unique ID: 0177722 Medline TA: Horm Metab Res Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 502-6 Citation Subset: IM |
Affiliation:
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Department of Chemical Pathology, University of Natal Medical School, Durban, Republic of South Africa. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Blood Glucose / analysis C-Peptide / blood* Female Glucose / administration & dosage, pharmacology Humans Hyperinsulinism / etiology Injections, Intravenous Insulin / blood* Polycystic Ovary Syndrome / blood*, complications |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/C-Peptide; 11061-68-0/Insulin; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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