Document Detail

Insufficient secretion of atrial natriuretic peptide at acute phase of myocardial infarction.
MedLine Citation:
PMID:  10926626     Owner:  NLM     Status:  MEDLINE    
To investigate the secretion of the plasma levels of atrial natriuretic peptide (ANP) in patients with acute myocardial infarction (AMI), we evaluated the relationship between plasma levels of ANP and pulmonary capillary wedge pressure (PCWP) in 45 consecutive patients during the acute phase of AMI ( approximately 12 h after the attack) (group 1) and compared data with those obtained after 1 mo (group 2). In both groups 1 and 2, plasma ANP levels significantly correlated with PCWP. The slope of the linear regression line between the PCWP and ANP in group 1 was significantly lower, by about one-third, than that in group 2. In addition, we examined changes in ANP levels and left ventricular end-diastolic pressure (LVEDP) over 180 min after AMI induced by injection of microspheres into the left coronary arteries of three dogs. The LVEDP and ANP levels 30 min after AMI were significantly higher than those before; however, despite the persistent high LVEDP during the 180 min after AMI, ANP levels decreased gradually and significantly to 63% of the peak level at 150 min. These findings suggest that the secretion of ANP during the acute phase of myocardial infarction may be insufficient relative to the chronic phase.
K Maeda; T Tsutamoto; A Wada; N Mabuchi; M Hayashi; T Hisanaga; T Kamijo; M Kinoshita
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  89     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-09-15     Completed Date:  2000-09-15     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  458-64     Citation Subset:  IM    
First Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan.
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MeSH Terms
Acute Disease
Atrial Natriuretic Factor / blood,  metabolism*
Blood Pressure / physiology
Cardiac Catheterization
Coronary Angiography
Hemodynamics / physiology
Middle Aged
Myocardial Infarction / metabolism*,  physiopathology
Natriuretic Peptide, Brain / blood,  metabolism
Pulmonary Wedge Pressure / physiology
Reg. No./Substance:
114471-18-0/Natriuretic Peptide, Brain; 85637-73-6/Atrial Natriuretic Factor

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