| Instrumental and dermatologist evaluation of the effect of glycerine and urea on dry skin in atopic dermatitis. | |
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MedLine Citation:
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PMID: 11737814 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: Moisturising creams are useful treatment adjuncts in inflammatory dermatoses and have beneficial effects in the treatment of dry, scaly skin. The effects on dryness and skin permeability of a new moisturising cream with 20% glycerine was compared with its placebo and with a medicinally authorised cream with 4% urea (combined with 4% sodium chloride) in the treatment of dry skin. METHODS: Patients (n=109) with atopic dermatitis were treated for 30 days with a moisturiser in a randomised, parallel and double-blind fashion. Transepidermal water loss (TEWL) and skin capacitance were assessed instrumentally, and changes in the dryness of the skin were assessed by the dermatologist. RESULTS: No difference in TEWL was found between glycerine treatment and its placebo, whereas a lower value was found in the urea-treated area compared to the glycerine-treated area. No difference in skin capacitance was found. The clinical assessment of dryness showed urea to be superior to glycerine in treating the condition. CONCLUSIONS: Moisturising creams are different, not only with respect to composition but also with respect to their influence on skin as a barrier to water in patients with atopic dermatitis. |
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Authors:
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M Lodén; A C Andersson; C Andersson; T Frödin; H Oman; M Lindberg |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) Volume: 7 ISSN: 0909-752X ISO Abbreviation: Skin Res Technol Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-12-11 Completed Date: 2002-04-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9504453 Medline TA: Skin Res Technol Country: Denmark |
Other Details:
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Languages: eng Pagination: 209-13 Citation Subset: IM |
Affiliation:
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ACO Hud AB, Stockholm, Sweden. marie.loden@acohud.se |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Body Water / metabolism* Dermatitis, Atopic / drug therapy*, metabolism*, physiopathology Double-Blind Method Galvanic Skin Response Glycerol / therapeutic use* Humans Middle Aged Ointments Skin / drug effects, metabolism* Urea / therapeutic use* Water Loss, Insensible |
| Chemical | |
Reg. No./Substance:
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0/Ointments; 56-81-5/Glycerol; 57-13-6/Urea |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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