Document Detail

Instrumental and dermatologist evaluation of the effect of glycerine and urea on dry skin in atopic dermatitis.
MedLine Citation:
PMID:  11737814     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Moisturising creams are useful treatment adjuncts in inflammatory dermatoses and have beneficial effects in the treatment of dry, scaly skin. The effects on dryness and skin permeability of a new moisturising cream with 20% glycerine was compared with its placebo and with a medicinally authorised cream with 4% urea (combined with 4% sodium chloride) in the treatment of dry skin. METHODS: Patients (n=109) with atopic dermatitis were treated for 30 days with a moisturiser in a randomised, parallel and double-blind fashion. Transepidermal water loss (TEWL) and skin capacitance were assessed instrumentally, and changes in the dryness of the skin were assessed by the dermatologist. RESULTS: No difference in TEWL was found between glycerine treatment and its placebo, whereas a lower value was found in the urea-treated area compared to the glycerine-treated area. No difference in skin capacitance was found. The clinical assessment of dryness showed urea to be superior to glycerine in treating the condition. CONCLUSIONS: Moisturising creams are different, not only with respect to composition but also with respect to their influence on skin as a barrier to water in patients with atopic dermatitis.
M Lodén; A C Andersson; C Andersson; T Frödin; H Oman; M Lindberg
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)     Volume:  7     ISSN:  0909-752X     ISO Abbreviation:  Skin Res Technol     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-12-11     Completed Date:  2002-04-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9504453     Medline TA:  Skin Res Technol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  209-13     Citation Subset:  IM    
ACO Hud AB, Stockholm, Sweden.
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MeSH Terms
Body Water / metabolism*
Dermatitis, Atopic / drug therapy*,  metabolism*,  physiopathology
Double-Blind Method
Galvanic Skin Response
Glycerol / therapeutic use*
Middle Aged
Skin / drug effects,  metabolism*
Urea / therapeutic use*
Water Loss, Insensible
Reg. No./Substance:
0/Ointments; 56-81-5/Glycerol; 57-13-6/Urea

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