Document Detail


Instrument independent diffuse reflectance spectroscopy.
MedLine Citation:
PMID:  21280897     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Diffuse reflectance spectroscopy with a fiber optic probe is a powerful tool for quantitative tissue characterization and disease diagnosis. Significant systematic errors can arise in the measured reflectance spectra and thus in the derived tissue physiological and morphological parameters due to real-time instrument fluctuations. We demonstrate a novel fiber optic probe with real-time, self-calibration capability that can be used for UV-visible diffuse reflectance spectroscopy in biological tissue in clinical settings. The probe is tested in a number of synthetic liquid phantoms over a wide range of tissue optical properties for significant variations in source intensity fluctuations caused by instrument warm up and day-to-day drift. While the accuracy for extraction of absorber concentrations is comparable to that achieved with the traditional calibration (with a reflectance standard), the accuracy for extraction of reduced scattering coefficients is significantly improved with the self-calibration probe compared to traditional calibration. This technology could be used to achieve instrument-independent diffuse reflectance spectroscopy in vivo and obviate the need for instrument warm up and post∕premeasurement calibration, thus saving up to an hour of precious clinical time.
Authors:
Bing Yu; Henry L Fu; Nirmala Ramanujam
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of biomedical optics     Volume:  16     ISSN:  1560-2281     ISO Abbreviation:  J Biomed Opt     Publication Date:    2011 Jan-Feb
Date Detail:
Created Date:  2011-02-01     Completed Date:  2011-05-31     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  9605853     Medline TA:  J Biomed Opt     Country:  United States    
Other Details:
Languages:  eng     Pagination:  011010     Citation Subset:  IM    
Affiliation:
Duke University, Department of Biomedical Engineering, Durham, North Carolina 27708, USA. bing.yu@duke.edu
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MeSH Terms
Descriptor/Qualifier:
Computer-Aided Design
Equipment Design
Equipment Failure Analysis
Fiber Optic Technology / instrumentation*
Lighting / instrumentation*
Pattern Recognition, Automated / methods*
Photometry / instrumentation*
Reproducibility of Results
Sensitivity and Specificity
Spectrophotometry, Ultraviolet / instrumentation*
Grant Support
ID/Acronym/Agency:
R01CA100559-01A1/CA/NCI NIH HHS
Comments/Corrections

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