Document Detail

Instantaneous versus average wave speed calculation in large mammals under acute hemorrhage.
MedLine Citation:
PMID:  18002120     Owner:  NLM     Status:  MEDLINE    
Arterial blood pressure and velocity pulse wave speed are important biomarkers of arterial stiffness and cardiovascular disease risk in man. Arterial wave speed is usually assessed using pulse wavefront movement over a known finite portion of the arterial tree. In our pilot study we assess a new technique for determining instantaneous wave speed using "wave intensity analysis" of simultaneously recorded high fidelity pressure and velocity waveforms at a single point in the porcine aorta during acute changes in hemodynamic status (hemorrhage). The results, when compared with a traditional wavefront approach over a length of aorta, suggest that the two techniques produce different results that could be explained by the varying properties along the aorta from heart to periphery. We show that instantaneous wave speed can be determined and monitored during acute hemodynamic change using "wave intensity analysis" at one point in the aorta. Furthermore, we uncovered discrepancies between instantaneous and averaged wave speed, which will be important in understanding the integrative physiology of acute cardiovascular perturbations and could have important application in monitoring the progression of chronic cardiovascular diseases.
C Quinsac; M Heil; A Jackson; P Dark
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference     Volume:  2007     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2007  
Date Detail:
Created Date:  2007-11-16     Completed Date:  2008-03-14     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  971-2     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Blood Pressure*
Blood Pressure Determination / methods*
Diagnosis, Computer-Assisted / methods*
Hemorrhage / diagnosis*,  physiopathology*
Pulsatile Flow*
Reproducibility of Results
Rheology / methods*
Sensitivity and Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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