Document Detail

Instantaneous end diastolic stiffness (IEDS): a simple, load independent measurement of left ventricular diastolic function in patients undergoing cardiac surgery.
MedLine Citation:
PMID:  10899694     Owner:  NLM     Status:  MEDLINE    
The end-diastolic pressure-volume relation is a load-independent measurement of diastolic function. However, its clinical utility is limited because of its complexity. Instantaneous end-diastolic stiffness (IEDS) is a simple to perform, single-point, measurement of ventricular stiffness. We have validated it against the end-diastolic pressure-area relation (EDPAR) in patients undergoing cardiac surgery. EDPARs were analyzed before and after cardiopulmonary bypass in 29 patients and compared with IEDS. Data was collected in an additional 69 patients in order to estimate the range of values of IEDS. End-diastolic area (EDA) measured by transesophageal echocardiography (TEE) was substituted for end-diastolic volume, and pulmonary capillary wedge pressure (PWCP) was substituted for end-diastolic pressure. IEDS = 100 x (log10 PWCP)/EDA. Comparison of the methods was done by ordinary least products regression analysis. Agreement between EDPAR and IEDS was identified by the absence of fixed and proportional bias. The maximal range of corresponding values identified by 95% confidence intervals was within +/- 16% of the mean indicating satisfactory agreement. The geometric mean and 95% confidence intervals (CI) for IEDS were 8. 7 mmHg/dm2 (8.1 to 9.4) and for IEDS indexed to body surface area were 17.2 mmHg/dm(2)/m2 (16.0 to 18.6). IEDS is a load independent index of left ventricular stiffness.
C F Royse; A G Royse; D W Blake; L E Grigg
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia     Volume:  6     ISSN:  1341-1098     ISO Abbreviation:  Ann Thorac Cardiovasc Surg     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-09-13     Completed Date:  2001-05-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9703158     Medline TA:  Ann Thorac Cardiovasc Surg     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  203-10     Citation Subset:  IM    
Department of Anaesthesia and Pain Management, The Royal Melbourne Hospital, P.O.Box 1022, Research, Victoria 3095, Australia.
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MeSH Terms
Cardiac Surgical Procedures*
Diastole / physiology
Echocardiography, Doppler*
Echocardiography, Transesophageal*
Heart Diseases / physiopathology*,  surgery,  ultrasonography
Middle Aged
Preoperative Care / methods*
Ventricular Function, Left / physiology*
Ventricular Pressure / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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