| Instant coffee with high chlorogenic acid levels protects humans against oxidative damage of macromolecules. | |
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MedLine Citation:
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PMID: 20589860 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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SCOPE: Coffee is among the most frequently consumed beverages. Its consumption is inversely associated to the incidence of diseases related to reactive oxygen species; the phenomenon may be due to its antioxidant properties. Our primary objective was to investigate the impact of consumption of a coffee containing high levels of chlorogenic acids on the oxidation of proteins, DNA and membrane lipids; additionally, other redox biomarkers were monitored in an intervention trial. METHODS AND RESULTS: The treatment group (n=36) consumed instant coffee co-extracted from green and roasted beans, whereas the control consumed water (800 mL/P/day, 5 days). A global statistical analysis of four main biomarkers selected as primary outcomes showed that the overall changes are significant. 8-Isoprostaglandin F2α in urine declined by 15.3%, 3-nitrotyrosine was decreased by 16.1%, DNA migration due to oxidized purines and pyrimidines was (not significantly) reduced in lymphocytes by 12.5 and 14.1%. Other markers such as the total antioxidant capacity were moderately increased; e.g. LDL and malondialdehyde were shifted towards a non-significant reduction. CONCLUSION: The oxidation of DNA, lipids and proteins associated with the incidence of various diseases and the protection against their oxidative damage may be indicative for beneficial health effects of coffee. |
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Authors:
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Christine Hoelzl; Siegfried Knasmüller; Karl-Heinz Wagner; Leonilla Elbling; Wolfgang Huber; Nina Kager; Franziska Ferk; Veronika Ehrlich; Armen Nersesyan; Oliver Neubauer; Aurélien Desmarchelier; Maricel Marin-Kuan; Thierry Delatour; Clotilde Verguet; Claudine Bezençon; Amélie Besson; Dominik Grathwohl; Tatjana Simic; Michael Kundi; Benoît Schilter; Christophe Cavin |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Molecular nutrition & food research Volume: 54 ISSN: 1613-4133 ISO Abbreviation: Mol Nutr Food Res Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101231818 Medline TA: Mol Nutr Food Res Country: Germany |
Other Details:
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Languages: eng Pagination: 1722-33 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, Vienna, Austria. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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