| Instabilities of metabolic regulations in aging. | |
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MedLine Citation:
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PMID: 1450606 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1) That non-invasive NMR and optical methods can a) quantify the work stress on mitochondria for ATP production, and b) indicate the tissue O2 tension in the capillary bed that is responsible for the rate of radical generation. 2) That free radical damage to mitochondrial function can be quantified by reciprocal plots of inverse slope giving the extrapolated Vm of mitochondria. 3) That a particular genetically deficient individual requiring high dosages of menadione has survived over 9 years. 4) That mitochondrial deficiency leads to an exercise hyperoxia. |
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Authors:
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B Chance; W W Bank; C Zhang |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: EXS Volume: 62 ISSN: 1023-294X ISO Abbreviation: EXS Publication Date: 1992 |
Date Detail:
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Created Date: 1993-01-06 Completed Date: 1993-01-06 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9204529 Medline TA: EXS Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 58-63 Citation Subset: IM; S |
Affiliation:
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Department of Biochemistry and Biophysics, Johnson Foundation, University of Pennsylvania, Philadelphia 19104. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Diphosphate
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metabolism Adenosine Triphosphate / metabolism Aging / metabolism* Animals Free Radicals / metabolism Homeostasis Humans Magnetic Resonance Spectroscopy / methods Mitochondria / metabolism* Models, Biological Muscles / metabolism Physical Exertion |
| Grant Support | |
ID/Acronym/Agency:
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AA07186/AA/NIAAA NIH HHS; HL18708/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Free Radicals; 56-65-5/Adenosine Triphosphate; 58-64-0/Adenosine Diphosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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