| Instabilities in phosphorylation-dephosphorylation cascades and cell cycle checkpoints. | |
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MedLine Citation:
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PMID: 10362255 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The G2-M checkpoint in the cell cycle is identified with a set of phosphorylation-dephosphorylation (PD) cycles involving Cdc25 and the maturation-promoting factor (MPF); these PD cycles are coupled in a way that generates an instability. This instability arises out of a transcritical bifurcation which could be exploited by the G2 DNA damage checkpoint pathway in order to arrest or delay entry into mitosis. The coupling between PD cycles involving Wee1 and MPF does not lead to an instability and therefore Wee1 may not be a crucial target of the checkpoint pathway. A set of PD cycles exhibiting transcritical bifurcation also possesses the integrative ability of a checkpoint for 'checking' that prerequisites are satisfied prior to the next cell cycle event. Such a set of coupled PD cycles is suggested to be a core mechanism of cell cycle checkpoints. |
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Authors:
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B D Aguda |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Oncogene Volume: 18 ISSN: 0950-9232 ISO Abbreviation: Oncogene Publication Date: 1999 May |
Date Detail:
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Created Date: 1999-06-25 Completed Date: 1999-06-25 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8711562 Medline TA: Oncogene Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 2846-51 Citation Subset: IM |
Affiliation:
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Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Catalysis Cell Cycle / physiology* Cell Cycle Proteins / metabolism Kinetics Maturation-Promoting Factor / metabolism Models, Molecular* Nuclear Proteins* Phosphoprotein Phosphatases / metabolism Phosphorylation Protein-Tyrosine Kinases / metabolism cdc25 Phosphatases |
| Chemical | |
Reg. No./Substance:
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0/Cell Cycle Proteins; 0/Nuclear Proteins; EC 2.7.10.1/Protein-Tyrosine Kinases; EC 2.7.11.22/Maturation-Promoting Factor; EC 3.1.3.16/Phosphoprotein Phosphatases; EC 3.1.3.48/cdc25 Phosphatases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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