Document Detail

Insomnia and depression during protective isolation in patients with hematological disorders.
MedLine Citation:
PMID:  20045996     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Patients treated in a protective isolation unit (PIU) often experience loneliness and increased feelings of seclusion, leading to elevated levels of distress, but the relationship between psychiatric distress and environmental factors is unclear. Therefore, we retrospectively compared the impact of environmental factors on insomnia and depression between patients in the PIU and those in a standard ward (SW). METHODS: Subjects were 246 patients with hematological disorders hospitalized in Meitetsu Hospital between April 1, 2007 and July 31, 2008 (62 PIU patients and 184 SW patients). We assessed insomnia and depression, as well as concomitant corticosteroid (CS) administration, stem cell transplantation (SCT) therapy, and complications resulting from these therapies. Details of medical history and patient information were retrospectively extracted from patients' charts, medical records and the electronic laboratory database at the hospital. RESULTS: Patients in the PIU tended to be complicated by insomnia or depression more than those in the SW, but the stay in the PIU was not significantly related to the incidence of insomnia or depression. Our findings indicated that use of CS was a risk factor for insomnia. The prevalence of depression was higher in patients with therapeutic complications. All PIU patients with depression also received SCT. CONCLUSION: Our findings suggest an increased potential for insomnia after administration of CS and depression in cases with complications after SCT, which is important to keep in mind for patients with hematological disorders.
Akane Kunitomi; Hiroatsu Iida; Yoshikazu Kamiya; Mayuko Hayashi; Taro Suwa; Junya Kanda; Hiroshi Sao
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Publication Detail:
Type:  Journal Article     Date:  2010-01-01
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  49     ISSN:  1349-7235     ISO Abbreviation:  Intern. Med.     Publication Date:  2010  
Date Detail:
Created Date:  2010-01-04     Completed Date:  2010-04-22     Revised Date:  2010-08-16    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  17-22     Citation Subset:  IM    
Department of Hematology, Meitetsu Hospital, Nagoya, Japan.
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MeSH Terms
Adrenal Cortex Hormones / adverse effects,  therapeutic use
Depression / etiology*
Hematologic Diseases / therapy*
Middle Aged
Odds Ratio
Patient Isolation / psychology*
Retrospective Studies
Risk Factors
Sleep Initiation and Maintenance Disorders / etiology*
Stem Cell Transplantation / psychology
Young Adult
Reg. No./Substance:
0/Adrenal Cortex Hormones
Comment In:
Intern Med. 2010;49(15):1689; author reply 1391   [PMID:  20686322 ]

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