Document Detail

Insignificant seasonal and geographical variation in incidence of biliary atresia in Japan: a regional survey of over 20 years.
MedLine Citation:
PMID:  18082714     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Biliary atresia (BA) is the leading cause of obstructive jaundice in the newborn and the major indication for liver transplantation in Japan. Viral infection has been implicated in its etiology because of seasonality and space clustering. However, this has been controversial among whites. The present study investigates space-time clustering of the incidence of BA in Japan. METHODS: Birth prevalence rates of BA were analyzed in infants born in Hyogo prefecture between 1985 and 2004 to assess time clustering among 3 seasons. The birth prevalence rates were also analyzed for space clustering between the northern (Hokkaido) and the southern islands (Kyushu) (difference of latitude, 10 degrees ) based on the Japanese Biliary Atresia Society Survey 1996-2004. We compared the prevalence rates between these groups using relative risks (RRs) calculated from 2 x 2 contingency tables. RESULTS: One hundred nineteen infants were born with BA in Hyogo (1.1/10000 live births). Seasonal clustering in April to July did not significantly differ from that of the reference period (RR, 1.45; 95% confidence interval, 0.93-2.27). Based on Japanese registry data, space clustering between the northern and southern islands did not significantly differ (RR, 1.24; 95% confidence interval, 0.83-1.86). CONCLUSIONS: Neither seasonal nor spatial clustering was statistically proven in Japan.
Hidemi Wada; Toshihiro Muraji; Akiko Yokoi; Tatsuya Okamoto; Shiiki Sato; Shigeru Takamizawa; Jiro Tsugawa; Eiji Nishijima
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  42     ISSN:  1531-5037     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-17     Completed Date:  2008-01-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2090-2     Citation Subset:  IM    
Division of Pediatric Surgery, Kobe Children's Hospital, Kobe, Hyogo 654-0081, Japan.
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MeSH Terms
Biliary Atresia / diagnosis,  epidemiology*
Cluster Analysis
Confidence Intervals
Health Surveys
Infant, Newborn
Japan / epidemiology
Neonatal Screening
Retrospective Studies
Severity of Illness Index
Sex Distribution

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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